摘要
目的探讨短期结构式心理教育对巴塞罗那临床肝癌分期为B/C期(BCLC-B/C)肝癌患者抑郁情绪及免疫功能的影响。方法采用便利抽样法,选取2016年6月—2018年3月在广西医科大学附属肿瘤医院肝胆外科住院的BCLC-B/C期肝癌患者210例为研究对象。依据医院焦虑抑郁量表(HADS-D)和患者健康问卷9(PHQ-9)量表评分将其分为无抑郁组(n=79)和抑郁组(n=131),将抑郁组随机患者分为干预组(n=66)和对照组(n=65)两个亚组。对无抑郁组和抑郁对照组患者给予常规护理,抑郁干预组在常规护理基础上给予短期结构式心理教育。采用HADS-D、PHQ-9、细胞免疫指标评价干预的效果。结果术后30d,抑郁干预组HADS-D、PHQ-9评分均低于对照组(P<0.01)。抑郁干预组术后30 d的CD3^+、CD3^+CD4^+、CD3^+CD4^+/CD3^+CD8^+水平高于抑郁对照组(P<0.05)。结论短期结构式心理教育能有效改善BCLC-B/C期肝癌患者的抑郁情绪和免疫功能,值得推广应用。
Objective To explore the effects of short-term structural psychological education on depression and immunity in patients with Barcelona clinic liver cancer B or C stage(BCLC-B/C)hepatocellular carcinoma.Methods Totally 210 patients with BCLC-B/C hepatocellular carcinoma who were admitted in the Department of Hepatological Surgery,Guangxi Medical University Affiliated Tumor Hospital from June 2016 to March 2018 were selected by convenient sampling and divided into the non-depression group(n=79)and the depression group(n=131)according to Hospital Anxiety and Depression Scale-Depression(HADS-D)and Patient Health Questionnaire(PHQ-9).Patients in the depression group were randomly divided into the intervention group(n=66)and the control group(n=65).Patients in the non-depression group and the depression-control group received conventional nursing care,while patients in the depression-intervention group received short-term structural psychological education on the basis of conventional nursing care.HADS-D,PHQ-9 and cytoimmunity indexes were used to evaluate the effects of intervention.Results The HADS-D and PHQ-9 scores of the depression-intervention group were lower than those of the control group on day 30 postoperatively(P<0.01).The CD3^+,CD3^+CD4^+,CD3^+CD4^+/CD3^+CD8^+levels of the depression-intervention group were higher than those of the depression-control group on day 30 postoperatively(P<0.05).Conclusions Short-term structural psychological education can effectively improve the depression and immunity in patients with BCLC-B/C,which is worth promoting in clinical practice.
作者
赵新华
赵凌云
韦珏伶
罗媚
游雪梅
Zhao Xinhua;Zhao Lingyun;Wei Jueling;Luo Mei;You Xuemei(Department of Hepatological Surgery,Guangxi Medical University Affiliated Tumor Hospital,Nanning 530021,China)
出处
《中华现代护理杂志》
2019年第14期1764-1768,共5页
Chinese Journal of Modern Nursing
基金
广西科技重大研发计划项目(桂科AB18126042)
广西卫计委中医药科技专项课题(GZLC16-36)
广西教育厅广西高校中青年教师基础能力提升项目(2017KY0098).
关键词
肝肿瘤
抑郁
结构式心理干预
免疫功能
Hepatocellular neoplasms
Depression
Structural psychological intervention
Immunity
