摘要
目的了解四川省绵阳市成人脂肪肝流行现况和代谢异常情况,分析其影响因素,为脂肪肝及其并发症的防治策略提供参考依据。方法采用多阶段分层随机抽样方法,于2014年11月1日至2015年9月30日在绵阳市抽取294603名18岁以上成人为调查对象,采用腹部B超诊断脂肪肝,通过问卷调查收集一般人口学特征、吸烟饮酒史、慢性病史等;同时随机抽取10217名调查对象进行生化检测(空腹血糖、三酰甘油、总胆固醇和谷丙转氨酶)。结果294603人中,17105人患有脂肪肝,患病率为5.81%,以2010年全国第6次人口普查结果为标准人口对年龄进行标化后标化率为5.32%;其中,男性脂肪肝患病率为6.76%(标化率为7.24%),明显高于女性的5.09%(标化率为4.08%)(χ^2=365.814,P<0.001)。现在吸烟者(8.52%)和既往吸烟者(8.89%),偶尔饮酒者(6.79%)、经常饮酒者(10.51%)和每天饮酒者(10.62%),高血压患者(12.14%),糖尿病患者(15.19%),冠心病患者(10.22%)脂肪肝检出率均明显高于无相应特征人群(P均<0.001)。多因素Logistic分析显示,体质量指数、舒张压、空腹血糖、三酰甘油、总胆固醇、谷丙转氨酶异常增高是影响脂肪肝患病的主要代谢因素。结论绵阳市成人脂肪肝流行水平相对偏低。脂肪肝患者常伴不同程度的血脂、血糖、血压和转氨酶等异常增高。纠正不良生活方式,综合评估其代谢指标有利于脂肪肝及肝外并发症的防治。
Objective To understand the prevalence and metabolic abnormalities of fatty liver disease among adults in Mianyang City,Sichuan Province,and to analyze their influencing factors. Methods Totally 294 603 adults aged 18 years and older were enrolled by using a multi-stage stratified random sampling method in Mianyang City from November 1,2014 to September 30,2015.Fatty liver was diagnosed by abdominal ultrasound.The general demographic characteristics,smoking history,drinking history,and history of chronic disease were collected through questionnaires. Meanwhile,10 217 subjects were randomly selected for biochemical tests [fasting plasma gluose(FPG),triacylglycerol(TG),total cholesterol(TC),and alanine aminotransferase(ALT)]. Results Of these 294 603 subjects,17 105(5.81%)had fatty liver.After having been age-adjusted based on the results of the sixth national census in 2010, the standardized prevalence was 5.32%.The prevalence was significantly higher in males(6.76%;standardized prevalence:7.24%)than in females(5.09%;standardized prevalence:4.08%)(χ^2=365.814, P <0.001).The prevalence of fatty liver disease was significantly higher in people with current smokers(8.52%)/ex-smokers(8.89%),occasional alcohol users(6.79%)/regular alcohol users(10.51%)/daily alcohol users(10.62%),and patients with hypertension(12.14%)/diabetes(15.19%)/coronary heart disease(10.22%)than those without corresponding characteristics(all P <0.001).Abnormal increase in body mass index,diastolic blood pressure,FPG,TG,TC,and ALT were risk factors for fatty liver in Logistic regression model. Conclusions The prevalence of fatty liver in adults is relatively low in Mianyang City.Patients with fatty liver usually have varying degrees of abnormal increase in blood lipids,blood glucose,blood pressure,and ALT.Healthy lifestyles and comprehensively assessment of metabolic status are conducive to the prevention and treatment of fatty liver and extrahepatic complications.
作者
余双彬
俞梦璐
陈曦
孙圆圆
张璇
侯富壤
闫柳清
高瑜阳
袁萍
YU Shuangbin;YU Menglu;CHEN Xi(Department of Epidemiology and Health Statistics,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2019年第3期323-330,共8页
Acta Academiae Medicinae Sinicae
基金
十二五国家科技重大专项(2012ZXl0004-901)~~
关键词
脂肪肝
横断面研究
影响因素
fatty liver
cross-sectional study
influence factors
