摘要
目的探讨微柱凝胶技术(MGT)检测孕妇血清Ig G抗体效价和新生儿溶血病(HDN)的相关性,为临床治疗和预防HDN提供参考依据。方法通过计算机检索国内外的数据库:Pub Med,EMBASE,中国知网,万方数据库以及维普中文科技期刊数据库,并且语种不限,纳入符合标准的病例对照研究,然后应用Stata 11.0软件对数据进行分析处理,合并优势比(OR)和95%的可信区间(95%CI),并且对相关数据进行异质性检验和发表偏倚的评价。结果本研究共计纳入15篇,9 452例病例。设定Ig G效价<64为正常参考值,孕妇血清Ig G抗A(B)效价≥64且<128,其血型不合胎儿发生ABO-HDN的相关性为:OR=8.76,95%CI=4.44~17.28,P=0.000、Ig G效价≥128且<256,ABO-HDN的相关性为:OR=22.74,95%CI=13.14~39.34,P=0.001、Ig G效价≥256且<512,ABO-HDN的相关性为:OR=54.54,95%CI=29.49~100.85,P=0.000、Ig G效价≥512,ABO-HDN的相关性为:OR=163.70,95%CI=90.21~297.07,P=0.009、Ig G效价≥64,ABO-HDN的相关性为:OR=29.72,95%CI=16.11~54.85,P=0.000。结论Ig G抗A(B)效价的阳性率与HDN的发病率有密切的相关性,从结果可以看出随着孕妇的Ig G抗A(B)效价的增高,HDN的发生率就越高,定期检测O型孕妇体内的Ig G抗A(B)效价的水平可以及早进行针对性治疗预防HDN的发生。
Objective To explore the correlation between serum IgG antibody titer of pregnant women with O blood type and hemolytic disease of newborn ( HDN) detected by micro-column gel agglutination assay ( MGT),provide a reference basis for clinical treatment and prevention of HDN. Methods Pubmed,EMBASE,CNKI,Wangfang database,and VIP were searched for case-control studies meeting the inclusion criteria,language restriction was avoided. Stata 11. 0 software was used to analyze the data. OR and 95% CI were calculated. Het- erogeneity test and publication bias evaluation were performed. Results A total of 15 studies containing 9 452 pregnant women were includ- ed. Taking the reference value of IgG antibody titer less than 64 as the normal reference value,when serum IgG anti-A ( B) titer≥64 and 128,OR= 8. 76,95% CI = 4. 44-17. 28,P = 0. 000;when serum IgG anti-A ( B) titer≥128 and <256,OR = 22. 74,95% CI = 13. 14- 39. 34,P= 0. 001;when serum IgG anti-A ( B) titer≥256 and <512,OR= 54. 54,95% CI = 29. 49-100. 85,P= 0. 000;when serum IgG anti-A ( B) titer≥512,OR = 163. 70,95% CI = 90. 21 - 297. 07,P = 0. 009;when serum IgG anti -A ( B) titer≥64,OR = 29. 72, 95% CI = 16. 11-54. 85,P = 0. 000. Conclusion The positive rate of IgG anti-A ( B) titer is closely correlated with incidence rate of HDN,the incidence rate of HDN increases with the elevation of IgG anti-A ( B) titer. Regular detection of IgG anti-A ( B) titer in pregnant women with O blood type can timely prevent HDN correspondingly.
作者
陈洋
王慧茹
周明
李娟
CHEN Yang;WANG Hui-Ru;ZHOU Ming(Anhui Provincial Hospital,the First Affiliated Hospital of University of Science and Technology of China,Hefei,Anhui 230001,China)
出处
《中国妇幼保健》
CAS
2019年第11期2646-2648,共3页
Maternal and Child Health Care of China
基金
安徽省自然基金(1708085QH198)
关键词
微柱凝胶技术
新生儿溶血病
IGG抗体效价
O型血孕妇
Micro-column gel agglutination assay
Hemolytic disease of newborn
IgG antibody titer
Pregnant woman with O blood type
