摘要
注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)是在儿童及青少年时期常见的神经精神障碍,其病因和发病机制尚不明确。中枢神经系统单胺氧化酶的表达异常造成单胺类神经递质的分解代谢改变,导致多巴胺/去甲肾上腺素水平紊乱,被认为与ADHD行为相关。单胺能系统与下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴之间存在着相互作用,HPA轴功能紊乱也被认为参与ADHD的发病机制。该文就ADHD中单胺类神经递质与HPA轴功能之间的相互影响及可能机制作一综述。
Attention deficit hyperactivity disorder(ADHD)is the most common neuropsychiatric disorder in children and adolescents.Its etiology and pathogenesis are still not clear.The disorder of monoamine oxidase function in the central nervous system that can result in abnormal catabolism of monoamine neurotransmitters, then lead to alteration of dopamine/norepinephrine levels, which is believed to be associated with ADHD behavior.Besides, dysfunction of the hypothalamic-pituitary-adrenal(HPA)axis is also involved in the pathogenesis of ADHD.In this review, the interaction between the monoaminergic system and HPA axis and its possible mechanism related with ADHD will be systematically summed up based on recent research.
作者
郑杰(综述)
陈燕惠(审校)
Zheng Jie;Chen Yanhui(Department of Pediatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China)
出处
《国际儿科学杂志》
2019年第5期370-374,共5页
International Journal of Pediatrics
基金
国家自然科学基金项目(81371262).
