摘要
目的探究慢性心理应激对痛经的影响,旨在对痛经的缓解提出心理层面的针对性建议。方法将12只雌性小鼠随机分成对照组和慢性应激组,对慢性应激组采用慢性束缚方式诱导慢性心理应激;再对慢性应激组和对照组小鼠建立痛经模型,通过扭体实验判断其痛经发生情况。结果对照组和慢性应激组之间扭体潜伏期、扭体次数均存在显著差异(P=0.042<0.05,P=0.012<0.05),慢性应激组扭体潜伏期更短,扭体次数更多。结论慢性心理应激可加重模型小鼠的痛经程度。
Objective To explore the effects of chronic restraint stress on dysmenorrhea in mice and put forward targeted suggestions on the psychological level to alleviate dysmenorrhea.Methods 12 female mice were randomly divided into control group and chronic stress group.Chronic psychological stress was induced by chronic restraint in chronic stress group,and then dysmenorrhea model was established in chronic stress group and control group,and dysmenorrhea was judged by writhing experiment.Results There were significant differences in the latency and times of writhing between the control group and the chronic stress group(P=0.042<0.05,P=0.012<0.05).The latency of writhing was shorter and the times of writhing were more in the chronic stress group.Conclusion Chronic psychological stress can aggravate dysmenorrhea.
作者
刘子钰
邓格
王菲迪
丰凯月
李泽雨
樊同祥
孙晓明
胡浩
李帆
LIU Ziyu;DENG Ge;WANG Feidi;FENG Kaiyue;LI Zeyu;FAN Tongxiang;SUN Xiaoming;HU Hao;LI Fan(Grade 2015 Hou Zonglian Medical Class;Basic Medical Experiment Teaching Center,Xi'an Jiaotong University,Xi'an 710061,China)
出处
《国外医学（医学地理分册）》
CAS
2019年第2期124-125,130,共3页
Foreign Medical Sciences：Section of Medgeography
关键词
慢性束缚应激
痛经
扭体实验
chronic restraint stress
dysmenorrhea
writhing test
