摘要
脂肪干细胞(adipose-derived stem cells,ADSCs)指由脂肪组织分离获得的成体间充质干细胞,因具有多项分化的潜能,且取材容易、来源广泛、体外增殖能力强,故拥有广泛的应用前景。大量实验研究表明,脂肪干细胞在对抗皮肤衰老具有较明显的作用,其作用机制和治疗效果的研究也是当代的医学热点。该文对脂肪干细胞的生物学性质、皮肤衰老的机制、脂肪干细胞抗皮肤衰老的机制和相关实验研究进行综述,并提出亟需解决的问题,为未来干细胞皮肤抗衰老治疗提供参考及借鉴意义。
Adipose-derived stem cells (ADSCs) are adult mesenchymal stem cells, which are derived from adipose tissue. ADSCs have broad applications, due to the potential of multiple differentiation, easy sampling, wide sources and high proliferation capacity in vitro. Many researches demonstrated that ADSCs have significant effects on anti-aging. Its mechanism and therapeutic effects also become a hot topic in recent years. This review summarized the biological characteristics of ADSCs, the mechanism of skin aging, the anti-aging mechanism of ADSCs, so as to provide reference for the use of ADSCs for skin anti-aging in the future.
作者
王诗萌
李甜
张维
杨田野
王家琪
张舵
Wang Shimeng;Li Tian;Zhang Wei;Yang Tianye;Wang Jiaqi;Zhang Duo(The First Hospital of Jilin University, Changchun 130000, China)
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2019年第5期513-518,共6页
Chinese Journal of Plastic Surgery
关键词
脂肪干细胞
皮肤老化
衰老
Adipose-derived stem cells
Skin-aging
Aging
