摘要
目的了解目标人群乙型肝炎免疫水平,评价免疫规划的有效性,为疾病预测和预防控制策略提供相关依据。方法采取分层随机抽样原则,在武汉市硚口区和江夏区各抽取480人,共采集960名监测对象的血清,采用SPSS20.0软件进行统计分析。结果健康人群8个年龄组乙型肝炎表面抗原(HBsAg)阳性率为3.23%,乙型肝炎病毒表面抗体(HBsAb)阳性率为72.19%;城乡、性别人群组HBsAg阳性率差异无统计学意义,年龄组间HBsAg阳性率差异有统计学意义(χ^2=20.218,P<0.01),职业组HBsAg阳性率差异有统计学意义(χ^2=19.055,P<0.05),文化程度组HBsAg阳性率差异有统计学意义(χ^2=14.18,P<0.05);城乡、性别、职业组HBsAb阳性率差异无统计学意义,文化程度组HBsAb阳性率差异不大,阳性率在67.79%~76.19%之间,年龄组间HBsAb阳性率差异有统计学意义(χ^2=66.596,P<0.01)。结论武汉市健康人群HBsAb阳性率明显高于2006年全国乙肝血清调查结果;乙肝疫苗接种是预防乙肝的重要常规免疫管理措施,今后的工作需要进一步提高疫苗接种率,特别是提高24h内新生儿首针及时接种率。
Objective To understand the immunity level of hepatitis B in the target population,evaluate the effectiveness of immunization program,and provide relevant evidence for disease prediction and prevention and control strategies. Methods The stratified random sampling principle was adopted. 480 people were randomly selected from each of Qikou District and Jiangxia District of Wuhan City. The serum was collected from the selected 960 subjects. The statistical analysis was conducted using SPSS20.0 software. Results In the healthy population of 8 age groups,the positive rate of hepatitis B surface antigen (HBsAg) was 3.23%,and the positive rate of hepatitis B virus surface antibody (HBsAb) was 72.19%. There was no significant difference in the positive rate of HBsAg between urban and rural groups. The difference of HBsAg positive rate between the age groups was statistically significant (χ^2=20.218, P <0.01). There was significant difference in the positive rate of HBsAg between different occupational groups (χ^2=19.055, P <0.05),as well as between different education level groups (χ^2=14.18, P <0.05). There was no significant difference in the positive rate of HBsAb between urban and rural,genders or occupational groups. A slight difference was observed in the positive rate of HBsAb in different education level groups,with the rate being 67.79% to 76.19%. In addition,there was a statistically significant difference in the positive rate of HBsAb among the different age groups (χ^2 = 66.596, P <0.01). Conclusion The positive rate of HBsAb in healthy people in Wuhan was significantly higher than that of 2006 national survey. Hepatitis B vaccination is an important routine immunization management measure to prevent hepatitis B.Future work needs to further improve the vaccination rate,especially to improve the rate of newborns within 24 hours of the first injection in time.
作者
张志峰
钟庆
蔡黎
文丽
陈剑
赵德峰
ZHANG Zhifeng;ZHONG Qing;CAI Li;WEN Li;CHEN Jian;ZHAO Defeng(Health Education Institute of Wuhan Center for Disease Control and Prevention Wuhan 430015,China)
出处
《公共卫生与预防医学》
2019年第3期91-94,共4页
Journal of Public Health and Preventive Medicine
关键词
健康人群
乙肝抗体
分析效果
监测
Healthy population
Hepatitis B antibody
Analysis of effectiveness
Monitoring
