摘要
IκB激酶β(IKKβ)是核因子κB(NF-κB)信号通路中的关键激酶。在脊髓损伤后,IKKβ被活化,NF-κB信号通路异常激活,产生大量炎症因子,对脊髓损伤后的恢复产生不利影响。本文主要对IKKβ的结构功能及其在脊髓损伤后炎症反应中的应用进行综述,试图寻找一种治疗脊髓损伤的新靶点。
IκB kinase beta (IKKbeta) is a key kinase in nuclear factor kappa B (NF-kappaB) signaling pathway.After spinal cord injury, IKKbeta is activated,and the signal pathway of NF-kappa B is abnormally activated,which produces a large number of inflammatory factors,which has a negative impact on the recovery of spinal cord injury.This article mainly summarized the structure and function of IKKbeta and its application in inflammatory reaction after spinal cord injury,trying to find a new target for the treatment of spinal cord injury.
作者
唐瑞苓
李敏
汪俊宇
向武
张安仁
TANG Rui-ling;LI Min;WANG Jun-yu;XIANG Wu;ZHANG An-ren(Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610037,China;Department of Rehabilitation Medicine,the General Hospital of Western Theater Command,Chengdu,Sichuan 610083,China)
出处
《中国康复理论与实践》
CSCD
北大核心
2019年第6期634-637,共4页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金面上项目(No.81674044)~~
关键词
IκB激酶β
脊髓损伤
炎症反应
核因子ΚB
综述
IκB kinase beta
spinal cord injury
inflammatory response
nuclear factor kappa B
review
