摘要
视神经脊髓炎(NMO)是一种中枢神经系统(CNS)自身免疫性疾病,主要表现为反复发作的视神经炎和急性横贯性脊髓炎。目前NMO的确切病因尚不明确,但遗传和环境因素之间的相互作用可能参与了NMO的发病过程。近年来有报道发现,肠道菌群与NMO的发病密切相关,且NMO患者肠道菌群中的产气荚膜梭菌(CPs)含量显著升高。该文通过复习国内外有关文献,对NMO与CPs相关性的研究进展进行综述,以期进一步明确NMO的发病原因,继而为临床治疗提供参考。
Neuromyelitis optica is an autoimmune astrocytopathy of the central nervous system mainly characterized by recurrent episodes of optic neuritis and acute transverse myelitis. Although the exact etiology and pathogenesis of NMO remain to be established, complex interactions between genetic and environmental factors are thought to be involved in its development.Studies have shown that the pathogenesis of NMO is closely related to gut microbiome, and the content of clostridium perfringens in gut microbiome of NMO patients was significantly increased. This article mainly reviews the correlation between the neuromyelitis optica and clostridium perfringens, in order to further clarify the pathogenesis of NMO and provide reference for clinical treatment.
作者
亓斐
谢沁芳
马莉花
鲍彩彩
牛彦霞
王满侠
QI Fei;XIE Qin-fang;MA Li-hua;BAO Cai-cai;NIU Yan-xia;WANG Man-xia(Department of Neurology,the Second Hospital of Lanzhou University,Lanzhou,730000,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2019年第5期430-433,共4页
Medical Journal of Chinese People's Liberation Army
基金
兰州市人才创新创业项目(2018-RC-74)
兰州市科技计划项目(2018-3-50)~~
关键词
视神经脊髓炎
肠道菌群
产气荚膜梭菌
neuromyelitis optica
gut microbiome
clostridium perfringens
