摘要
目的探讨X射线损伤交叉互补蛋白1(XRCC1)基因多态性与三阴性乳腺癌(TNBC)患者预后的相关性。方法选择2013年1月至2015年1月上海交通大学医学院附属第九人民医院确诊的女性原发性TNBC患者,选取XRCC1基因Arg280His、Arg399Gln及Arg194Trp对患者进行基因分型,并根据患者预后情况分成生存组及死亡组,采用Logistic回归分析XRCC1基因型与预后的关系。结果研究共入选130例患者,年龄(50.4 ± 6.3)岁,随访时间(45 ± 13)个月,其中死亡组患者62例,生存组68例。死亡组较生存组患者年龄更大[(52.6 ± 6.7)岁比(48.3 ± 5.2)岁,P < 0.01],淋巴结转移比例更高[88.7%(55/62)比73.5%(50/68),P=0.028]。XRCC1基因Arg399Gln基因型频率在生存组及死亡组分布为:GG:61.8%比38.7%;GA:32.4%比41.5%;AA:5.9%比19.4%,P=0.011,等位基因频率两组间比较也差异有统计学意义,其中A等位基因频率在死亡组中明显高于生存组(40.4%比22.0%,P < 0.01)。Arg399Gln多态性A等位基因的加性模型时,每增加一个A等位基因拷贝,风险是增加前的1.443倍(95% CI 1.174~ 1.793,Bonferroni校正后P值< 0.01)。校正年龄及淋巴结转移情况后,A等位基因仍然显著增高患者死亡风险(OR=1.533,95% CI 1.254~1.903,Bonferroni校正后P < 0.01)。结论XRCC1基因Arg399Gln多态性与TNBC患者预后相关,携带A等位基因的患者预后差。
Objective To investigate the relationship between X-ray injury cross-complementing protein 1 (XRCC1) gene polymorphism and prognosis in patients with triple-negative breast cancer (TNBC). Methods Patients with primary triple-negative breast cancer (TNBC) diagnosed in the Ninth People′s Hospital, Shanghai Jiaotong University School of Medicine from January 2013 to January 2015 were selected. Patients were selected for genotyping (XRCC1 gene Arg280His, Arg399Gln and Arg194Trp) and divided into survival group and death group according to the prognosis of patients. Logistic regression was used to analyze the relationship between XRCC1 genotype and prognosis. Results A total of 130 patients were enrolled in the study, with an average age of (50.4 ± 6.3) years. The mean follow-up time was (45 ± 13) months, including 62 patients with breast cancer-related deaths and 68 patients with survival. The patients in death group was older than those in the survival group [(52.6 ± 6.7) years vs.(48.3 ± 5.2) years, P < 0.01), and and the lymph node metastasis rate was higher [88.7%(55/62) vs.73.5%(50/68), P=0.028]. The frequency of XRCC1 gene Arg399Gln genotype in the survival and death group was GG: 61.8% vs. 38.7%;GA: 32.4% vs. 41.5%;AA: 5.9% vs. 19.4%, P=0.011.There were also statistical differences between the two groups in the frequency of allele, and the frequency of A allele was significantly higher in the death group than in the survival group (40.4% vs. 22.0%, P < 0.01). For the additive model of the Arg399Gln polymorphism A allele, for each additional copy of the A allele, the risk was 1.443 times that before the increase (95% CI 1.174-1.793, P < 0.01). After adjusting for age and lymph node metastasis, the A allele still significantly increased the risk of death (OR=1.533, 95% CI 1.254-1.903, P < 0.01). Conclusions The XRCC1 gene Arg399Gln polymorphism is associated with the prognosis of TNBC, and patients with the A allele have a poor prognosis.
作者
施丹丽
卞邦健
樊强
王守练
王和贤
Shi Danli;Bian Bangjian;Fan Qiang;Wang Shoulian;Wang Hexian(Department of General Surgery, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China)
出处
《中国医师进修杂志》
2019年第6期510-514,共5页
Chinese Journal of Postgraduates of Medicine
基金
上海交通大学医学院附属第九人民医院院级基金(JY201701123).
关键词
三阴乳腺癌
X射线损伤交叉互补蛋白1
多态性
预后
Triple-negative breast cancer
X-ray injury cross-complementing protein 1
Polymorphism
Prognosis
