摘要
目的观察在拉米夫定耐药慢性乙型病毒性肝炎(CHB)患者中应用恩替卡韦治疗的临床效果分析。方法方便选取在该院近期(2015年7月-2018年2月时期)收治拉米夫定耐药CHB患者总计60例,均采取恩替卡韦治疗6个月,并对患者进行4个月的有效随访。对照治疗后不同时间段的临床效果,不良反应发生率及肝功能、乙型肝炎病毒脱氧核糖核酸(HBV-DNA)变化。结果患者入组后治疗第1个月显效率为53.33%,有效率为16.67%,总有效率为70.00%;治疗第2个月显效率为68.33%,有效率为10.00%,总有效率为78.33%;治疗第3个月显效率为76.67%,有效率为8.33%,总有效率为80.00%;治疗第4个月显效率为81.67%,有效率为8.33%,总有效率为90.00%(P=0.001)。治疗前患者肝功能指标及HBV-DNA指标水平较高,治疗后肝功能指标及HBV-DNA指标水平较治疗前明显下降,差异有统计学意义(P=0.002)。结论对于拉米夫定耐药CHB患者患者而言,采取恩替卡韦治疗,可获得较好的临床治疗效果,并发症较低且可明显改善患者肝功能,降低HBV-DNA表达量,效果理想。
Objective To observe the clinical effect of entecavir in patients with lamivudine-resistant chronic hepatitis B(CHB). Methods A total of 60 patients with lamivudine-resistant CHB treated with entecavir for 6 months in our hospital(July 2015 to February 2018) were convenient selected. The patients were followed up for 4 months. The clinical effects, incidence of adverse reactions, liver function and changes of hepatitis B virus deoxyribonucleic acid(HBV-DNA) at different time points after treatment were compared. Results One month after treatment. The marked effective rate was 53.33%, the effective rate was 16.67%, the total effective rate was 70.00%. Two months after treatment, the marked effective rate was68.33%, the effective rate was 10.00%, the total effective rate was 78.33%. Three months after treatment, the marked effective rate was 76.67%, the effective rate was 8.33%, the total effective rate was 80.00%. Four months after treatment, the marked effective rate was 81.67%, the effective rate was 8.33% and the total effective rate was 90.00%(P=0.001). The level of liver function index and HBV-DNA index before treatment was high, and the level of liver function index and HBV-DNA index after treatment decreased significantly. The difference was statistically significant(P=0.002). Conclusion Entecavir is effective in the treatment of the patients with lamivudine-resistant CHB. It can improve liver function, reduce complications and the expression of HBV-DNA.
作者
蔡乐斌
陶娜
郭文
CAI Le-bin;TAO Na;GUO Wen(Department of Emergency,First People's Hospital(The Second Affiliated Hospital of South China Liniversity of Fechndogy),Guangdong,Guangzhou Province,510180 China)
出处
《中外医疗》
2019年第12期122-124,共3页
China & Foreign Medical Treatment
