摘要
帕金森病(PD)起病隐匿,目前多依据患者表现出典型的运动性症状来诊断,但此时往往已进入疾病进展期且难以逆转,某些非运动性症状如嗅觉障碍、快动眼期睡眠行为障碍、自主神经功能障碍、抑郁、视觉障碍、认知功能障碍等虽然出现更早,但易被患者和医务人员忽视,充分了解PD患者的非运动性症状,有利于PD的早期识别与诊断。近年来,多巴胺转运体示踪剂、多巴胺受体显像、葡萄糖代谢显像、经颅超声成像以及血清表皮生长因子、血清胱抑素、血清尿酸水平等生物学标志物的检测不仅用于早期PD的识别与诊断,也是评价治疗效果和预后的良好指标,与非运动症状共同成为早期PD的预警标志。
Motor symptoms are the typical clinical characteristics of Parkinson′s disease(PD), which indicates an irreversible and progressive stage. Some non-motor symptoms such as dysosmia,rapid eye movement behavior disorder,autonomic dysfunction,depression, disopsia and cognitive dysfunction,appear earlier than motor symptoms but are usually ignored by the patients and physicians. Therefore,comprehensive understanding of non-motor symptoms contributes to early detection and diagnosis.Moreover,some biomarkers such as dopamine transporter tracer,dopamine receptor imaging,glucose metabolism imaging, transcranial ultrasound imaging,serum epidermal growth factor,cystatin and uric acid, are also used in the early diagnosis, evaluation of the treatment efficacy and the prognosis of PD.
作者
周锦霞
潘春联
郑丽芳
ZHOU Jingxia;PAN Chunlian;ZHENG Lifang(Department of Neurology,Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430081,China)
出处
《医学综述》
2019年第11期2238-2241,2247,共5页
Medical Recapitulate
关键词
帕金森病
早期
预警
Parkinson′s disease
Early
Warning
