摘要
冠状动脉慢血流(CSF)的发病机制尚不明确,目前尚无统一有效的治疗方法。近年来关于CSF发病机制的研究主要集中在基因多态性与疾病遗传易感性的相关领域。对于血管内皮收缩因子与舒张因子的基因多态性、炎症细胞因子的基因多态性(白细胞介素、淋巴毒素、细胞间黏附分子1)以及其他与CSF相关的基因多态性与CSF发病是否相关,尚无定论。深入研究CSF中的遗传易感性并寻找CSF的遗传预警标志,可为预防及个体化治疗CSF提供临床依据。
The pathogenesis of coronary slow flow(CSF) is unclear,and there is no uniform and effective treatment yeat .In recent years,studies on the pathogenesis of CSF have focused on the correlation between the genetic polymorphism and genetic susceptibility.The association of gene polymorphism of vascular endothelial contraction factor and relaxing factor,inflammatory cytokines(interleukin,lymphotoxin,intercellular adhesion molecule- 1) and other gene polymorphisms with the pathogenesis of CSF is still undefined.Exploring the genetic susceptibility in the pathogenesis of CSF and finding an early genetic warning sign can provide a clinical basis for the prevention and individualized treatment of CSF.
作者
朱晴
赵翠婷
王永槐
李光源
孟平平
孔凡鑫
马春燕
杨军
ZHU Qing;ZHAO Cuiting;WANG Yonghuai;LI Guangyuan;MENG Pingping;KONG Fanxin;MA Chunyan;YANG Jun(Department of Cardiovascular Ultrasound,the First Hospital of China Medical University,Shenyang 110001,China)
出处
《医学综述》
2019年第7期1292-1296,共5页
Medical Recapitulate
基金
辽宁省高等学校基本科研项目(LQNK201701)
沈阳市中青年科技创新人才支持计划(RC170557)
关键词
冠状动脉慢血流
基因多态性
遗传易感性
内皮功能
炎症
Coronary slow flow
Genetic polymorphism
Geneticsusceptibility
Endothelial function
Inflammation
