摘要
目的探讨重症急性胰腺炎患者采用乌司他丁与奥曲肽治疗的预后及血流变学指标变化情况。方法收集2016年12月至2018年7月本院进行治疗的80例重症急性胰腺炎患者的临床资料,按照治疗方案不同分为观察组40例和对照组40例,两组患者确诊后即给予常规对症治疗,对照组患者给予奥曲肽治疗,观察组患者给予乌司他丁+奥曲肽治疗,比较两组患者疗程结束时预后效果、治疗期间并发症发生情况及治疗前后血流变学指标变化情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后全血高切黏度、血浆黏度、血小板黏附率均低于对照组,差异有统计学意义(P<0.05);观察组患者治疗期间并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论乌司他丁与奥曲肽治疗重症急性胰腺炎疗效显著,可明显改善患者血流变学指标,降低并发症发生风险,值得临床推荐。
Objective To investigate the prognosis and hemorheological changes of patients with severe acute pancreatitis treated with Ulinastatin and octreotide. Methods The clinical data of 80 patients with severe acute pancreatitis treated in our hospital from December 2016 to July 2018 were collected and divided into observation group (40 cases) and control group (40 cases) according to different treatment schemes. The patients in the two groups were given routine symptomatic treatment immediately after diagnosis. The patients in the control group were given octreotide treatment. The patients in the observation group were given Ulinastatin + octreotide treatment. The treatment course of the two groups was compared. The prognostic effect, complications during treatment and changes of hemorheological parameters before and after treatment were observed. Results The total effective rate of the observation group was higher than that of the control group, with statistical significance (P<0.05);the whole blood high shear viscosity, plasma viscosity and platelet adhesion rate of the observation group were lower than those of the control group after treatment, with statistical significance (P<0.05);the total incidence of complications of the observation group was lower than that of the control group during treatment, with statistical significance (P<0.05). Conclusion Ulinastatin and octreotide are effective in the treatment of severe acute pancreatitis. They can significantly improve the hemorheological parameters and reduce the risk of complications, which is worthy of clinical recommendation.
作者
简玲丽
杨烨
Jian Lingli;Yang Ye(Department Of Gastroenterology, General Hospital, Pingxiang Mining Group Co, LTD, Pingxiang, Jiangxi, 337000, China;Department Of General Surgery, General Hospital Of Pingxiang Mining Group Co, LTD, Pingxiang, 337000, China)
出处
《当代医学》
2019年第18期52-54,共3页
Contemporary Medicine
关键词
重症急性胰腺炎
乌司他丁
奥曲肽
血流变学指标
预后
Severe acute pancreatitis
Ulinastatin
Octreotide
Hemorheological parameters
Prognosis
