摘要
采用二硫化钼(MoS_2)表面接枝硫辛酸(LA)修饰的聚乙二醇(PEG)(LA-PEG),以增加其生物相容性,进一步接枝聚乙烯亚胺(PEI),用以连接牛血清蛋白(BSA)修饰的叶酸(FA),构建主动靶向体系叶酸-牛血清蛋白-聚乙烯亚胺-硫辛酸-二硫化钼-硫辛酸-聚乙二醇(FA-BSA-PEI-LA-MoS_2-LA-PEG),并对产物的形貌及理化性质进行测试。研究结果表明,制得的产物的水动力学直径约133nm,适合用作抗癌药物载体,以阿霉素(DOX)为模型药物,研究产物的载药能力和体外药物释放行为,在pH=5.0,近红外光照射条件下,经过68h,产物负载的DOX的累计释放量为67.8%,具有良好的载药能力和应用价值。
Lipophilic(LA)modified polyethylene glycol(PEG)(LA-PEG)was grafted to the surface of molybdenum disulfide(MoS2)to improve its biocompatibility,and further modified by graft polyethylenimine(PEI)which was used to link bovine serum albumin(BSA)modified folic acid(FA).Thus the drug delivery system FA-BSAPEI-LA-MoS2-LA-PEG was constructed.The morphology and physicochemical properties of materials were characterized.The hydrodynamic size of materials was 133 nm,which was suitable for using as a carrier of anticancer drugs.The drug loading efficiency and in vitro drug release behavior of complexes were investigated with DOX as model drug.The results showed that the cumulative drug release was 67.8%after 68 hwith NIR at pH 5.0.The drug delivery system had good drug-loading ability as well as application value.
作者
章学易
吴建荣
钱倩倩
牛世伟
朱利民
Zhang Xueyi;Wu J ianrong;Qian Qianqian;Niu Shiwei;Zhu Limin(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620)
出处
《化工新型材料》
CAS
CSCD
北大核心
2019年第5期269-272,共4页
New Chemical Materials
基金
上海市科学技术委员会资助项目(16410723700)
生物医用纺织材料"111工程"中国教育部(B07024)
关键词
二硫化钼
近红外光刺激响应
PH敏感
药物控释
乳腺癌靶向
molybdenum disulfide
near-infrared light stimulus response
pH stimulus response
drug controlled release
breast cancer targeting
