摘要
在乙型肝炎病毒(hepatitis B virus, HBV)感染期间可见到广泛的免疫介导的肝损伤. HBV免疫清除的失败从而导致慢性乙型肝炎(chronic hepatitis B, CHB),并大大增加肝硬化和肝细胞癌的风险. T淋巴细胞在HBV感染中的免疫反应起重要作用,尤其是调节性T细胞(regulatory T cell, Treg)和辅助性T细胞17(helper T cell 17, Th17)失衡的问题,二者的平衡失调是HBV持续感染与肝脏炎性损伤的重要机制.为了更好地揭示潜在的机制,在本综述中,我们系统地回顾了Treg和Th17,讨论了在HBV感染后Treg与Th17两者之间的关系,并对特异性转录因子维甲酸相关核孤儿受体γt(retinoid-related orphan nuclear receptorγt, RORγt)和叉头/翅膀状螺旋转录因子3(forkhead/winged helix family transcription factor 3, Foxp3)两者之间的变化,随着近几年对HBV免疫靶向治疗研究的不断深入,Foxp3/Treg与RORγt/Th17的平衡似乎对HBV的感染至关重要,以此为契机可以为CHB的治疗提供新的思路.
A wide range of immune-mediated liver damage can be seen during infection with hepatitis B virus(HBV).Failure of HBV immune clearance leads to chronic hepatitis and greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. Recently, there have been many studies on the relationship between the outcome of HBV infection and the immune status of patients. The immune response of T lymphocytes in HBV infection plays an important role, especially the imbalance of regulatory T cells(Treg)/Helper T cell 17(Th17). The imbalance between the Treg and Th17 is an important mechanism of persistent HBV infection and inflammatory injury of the liver. To better reveal the underlying mechanisms, we systematically review the roles of Treg and Th17 and discuss the relationship between Treg and Th17 during HBV infection as well as the changes in the two related specific transcription factors, retinoid-related orphan nuclear receptor γt(RORγt) and forkhead/winged helix family transcription factor 3(Foxp3). The research on HBV immunotargeting therapy in recent years has suggested the role of Foxp3/Treg and RORγt/Th17 imbalance in HBV infection. Such findings provide new ideas for the treatment of chronic hepatitis B.
作者
贾冠华
游晶
李静
范晶华
Guan-Hua Jia;Jing You;Jing Li;Jing-Hua Fan(Department of Infectious Diseases,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Province,China;Kunming Medical University,Kunming 650500,Yunnan Province,China)
出处
《世界华人消化杂志》
CAS
2019年第11期709-714,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目,No.81760111
昆明医科大学研究生创新基金,No.2018S103~~
