摘要
目的探讨不同稳态模型胰岛素抵抗指数(HOMA-IR)的多囊卵巢综合征(PCOS)患者的临床特征及生化水平的差异,为临床治疗提供依据。方法294例PCOS患者根据HOMA-IR分为3组:A组(HOMA-IR<1.66),B组(1.66≤HOMA-IR<2.69),C组(HOMA-IR≥2.69),比较各组的临床特征和生化水平。结果A、B、C3组的构成比分别为15.66%、22.49%、61.85%。B、C组的初潮年龄高于A组。C组的体重、体重指数(BMI)、腰围、臀围、WHR和黑棘皮发生率较A、B组高。C组的多毛和痤疮的发生率较A组高。C组的促黄体生成素(LH)、LH/FSH(促卵泡生成素)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)高于A组和B组,SHBG和HDL-C低于A组和B组。C组的PRL低于B组,FPG和FINS为C组>B组>A组(P<0.05)。HOMA-IR与年龄、体重、BMI、腰围、臀围和WHR、LH、LH/FSH、TG、TC、LDL-C、FPG、FINS均呈正相关,与SHBG和HDL-C呈负相关。结论IR与PCOS患者临床特征与生化水平之间存在一定的相关性,将HOMA-IR以2.69作为分界点时,PCOS患者出现明显的临床特征及生化水平的异常,因此对于HOMA-IR≥2.69的PCOS患者临床应给予重视,预防疾病的进一步发展。
Objective To explore the differences of clinical characteristics and biochemical levels in patients of polycystic ovary syndrome (PCOS) with different homeostasis model assessment insulin resistance index(HOMA-IR),and to provide a basis for clinical treatment.Methods Totally 294 cases patients of PCOS were divided into three groups according to the HOMA-IR:group A (HOMA- IR<1.66),group B (1.66≤HOMA-IR<2.69),group C(HOMA-IR≥2.69),to compare the clinical characteristics and biochemical level of each group.Results The constituent ratios of A,B and C three groups were 15.66%,22.49% and 61.85% respectively.The age of menophania in group B and C was higher than that in group A.The weight,BMI,waist,hip,WHR and the incidence of acanthosis nigricans in group C were higher than those in group A and B,and the incidences of hairy and acne in group C were higher than those in the group A.The LH,LH/FSH,TG,TC and LDL-C were higher than those in group A and B,SHBG and HDL-C in group C were lower than those in group A and B.The PRL in group C was lower than in group B.The FPG and FINS in three groups were group C>group B>group A( P <0.05).HOMA-IR was positively correlated with age,weight,BMI,waist circumference,hip circumference and WHR,LH,LH/FSH,TG,TC,LDL-C,FPG,FINS,and negatively correlated with SHBG and HDL-C levels.Conclusion There is a certain correlation between IR and PCOS,and when the HOMA-IR is 2.69 as a demarcation point,PCOS patients have obvious clinical biochemical level abnormality,so the PCOS patients with HOMA-IR≥2.69 should be paid more attention to prevent the occurrence of further development of the disease.
作者
张红阳
侯丽辉
李妍
王颖
Zhang Hongyang;Hou Lihui;Li Yan(Heilongjiang University of Chinese Medicine,Heilongjiang 150040,China)
出处
《医学研究杂志》
2019年第5期82-85,共4页
Journal of Medical Research
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题资助项目(JDZX2012039)
国家中医药管理局全国名老中医药专家传承工作室建设项目(2014-9-10)
国家中医药管理局基金资助项目(JDZX2015058)
黑龙江省中医药管理局基金资助项目(2HY12-W008)
黑龙江省教育厅基金项目(12531651)
黑龙江省中医药科研项目(ZHY16-029)
2016年黑龙江省政府博士后资助项目(LBH-Z16199)
关键词
多囊卵巢综合征
稳态模型胰岛素抵抗指数
相关性
Polycystic ovary syndrome
Homeostasis model assessment insulin resistance index
Correlation
