摘要
目前支气管哮喘的发病率日益增高,其发病机制复杂,涉及基因、免疫、炎症以及环境等多方面。1,25-(OH)2D3是人体内维生素D(VitD)最重要的活性代谢产物,不仅是骨代谢及钙稳态的关键调控因子,同时在支气管哮喘的发病中也发挥着重要的调节作用。VitD基因的多态性及自身均参与支气管哮喘的免疫调节、炎症反应、气道重塑及激素抵抗等多种重要机制的发生和发展。深入研究VitD在支气管哮喘治疗中的潜在机制,可为支气管哮喘的治疗提供新的途径,以改善患者的生活质量。
At present,the incidence of bronchial asthma is increasing.Its pathogenesis is complicated,involving genes,immunity,inflammation and the environment.1,25-(OH)2D 3 is the most important active metabolite of vitamin D(Vit D) in human body.It not only is a key regulator of bone metabolism and calcium homeostasis,but also plays an important regulatory role in the pathogenesis of bronchial asthma.The polymorphism of Vit D gene and itself are involved in the development of various important mechanisms such as bronchial asthma immunoregulation,inflammatory response,airway remodeling and hormone resistance.Further study of the potential mechanism of Vit D in the treatment of bronchial asthma can provide a new way for the treatment and improve the quality of life of the patients.
作者
闫玉晓
严俊
李宇宁
YANYuxiao;YAN Jun;LI Yuning(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China)
出处
《医学综述》
2019年第10期1921-1925,共5页
Medical Recapitulate
关键词
支气管哮喘
维生素D
基因多态性
发病机制
激素抵抗
Bronchial asthma
Vitamin D
Genetic polymorphism
Pathogenesis
Steroid resistance
