摘要
目的 探讨慢性乙型肝炎(CHB)和乙型肝炎肝硬化患者血清高尔基体蛋白73(GP73)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原、层粘连蛋白(LN)水平及其临床意义。方法 选取CHB患者30例(CHB组),乙型肝炎肝硬化患者36例(肝硬化组),以及健康体检者31例(对照组)。比较3组血清GP73、PCⅢ、Ⅳ型胶原、LN水平,分析CHB组及肝硬化组患者GP73水平与PCⅢ、Ⅳ型胶原、LN水平的相关性。结果 CHB组与肝硬化组患者GP73、PCⅢ、Ⅳ型胶原、LN水平均高于对照组,肝硬化组患者GP73、Ⅳ型胶原、LN水平均高于CHB组(均P<0.05)。CHB组患者血清GP73水平与PCⅢ及Ⅳ型胶原水平呈正相关,肝硬化组患者血清GP73水平与Ⅳ型胶原水平呈正相关(均P<0.05)。结论 GP73、Ⅳ型胶原、LN可能与CHB和乙型肝炎肝硬化的发生有关,GP73联合PCⅢ或Ⅳ型胶原或有助于提高其对CHB和乙型肝炎肝硬化的诊断效能。
Objective To investigate serum Golgi protein 73(GP73),typeⅢprocollagen(PCⅢ),typeⅣcollagen and laminin(LN)levels and their clinical significance in patients with chronic hepatitis B(CHB)and hepatitis B virus(HBV)-related cirrhosis.Methods Thirty patients with CHB(CHB group),36 patients with HBV-related cirrhosis(cirrhosis group),and 31 healthy check-up individuals(control group)were enrolled in the study.Serum levels of GP73,PCⅢ,typeⅣcollagen and LN were compared among the three groups,and the correlation of serum GP73 level with PCⅢ,typeⅣcollagen or LN level was analyzed in the CHB group and cirrhosis group.Results The CHB group and the cirrhosis group had higher levels of GP73,PCⅢ,typeⅣcollagen and LN than the control group,the cirrhosis group had higher levels of GP73,typeⅣcollagen and LN than the CHB group(all P<0.05).Serum GP73 level positively correlated with PCⅢor typeⅣcollagen level in the CHB group,and positively correlated with typeⅣcollagen level in the cirrhosis group(all P<0.05).Conclusion GP73,typeⅣcollagen,and LN might be associated with the occurrence of CHB and HBV-related cirrhosis,GP73 combined with PCⅢor typeⅣcollagen might contribute to improving the diagnostic efficiency for CHB and HBV-related cirrhosis.
作者
申文晓
赵永忠
秦韬
叶亮
王雪梅
曹杰
覃桂金
郑清华
SHEN Wen-xiao;ZHAO Yong-zhong;QIN Tao;YE Liang;WANG Xue-mei;CAO Jie;QIN Gui-jin;ZHENG Qing-hua(Department of Gastroenterology,Head and Neck Surgery,Affiliated Hospital of Guilin Medical University,Guilin 541001,China;Department of Laboratory Medicine,Head and Neck Surgery,Affiliated Hospital of Guilin Medical University,Guilin 541001,China;Department of Otolaryngology,Head and Neck Surgery,Affiliated Hospital of Guilin Medical University,Guilin 541001,China)
出处
《广西医学》
CAS
2019年第10期1227-1230,共4页
Guangxi Medical Journal
基金
广西桂林市科学研究与技术开发计划(20170109-19)
