摘要
脓毒症是由感染引起的宿主免疫反应异常而导致的威胁生命的器官功能障碍综合征。细胞焦亡是新近发现的一种依赖天冬氨酸特异性半胱氨酸蛋白酶(caspase-1、caspase-11、caspase-4、caspase-5),以释放炎性因子白细胞介素-1β(IL-1β)和IL-18为特征的程序性细胞死亡方式。本文通过综述细胞焦亡的分子机制以及焦亡与脓毒症的相关研究,为脓毒症治疗提供新思路与新靶点。
Sepsis is an organ dysfunction syndrome caused by an abnormal host immune response because of infection. Pyroptosis is a newly discovered programmed cell death relies on caspase-1, caspase-11, caspase-4, caspase-5 and is characterized by the release of inflammatory cytokines interleukin-1β(IL-1β) and IL-18. The exploration of the molecular mechanisms of pyroptosis and the correlation between pyroptosis and sepsis can provide new ideas and new targets for the treatment of sepsis.
作者
沈灵芝
李莉
严静
Shen Lingzhi;Li Li;Yan Jing(Department of Critical Care Medicine,Zhejiang Hospital,Hangzhou 310013,Zhejiang,China;Wenzhou Medical University,Wenzhou 325000,Zhejiang,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2019年第4期498-500,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金(81772051)
浙江省中医药科技项目(2019ZB004).
关键词
脓毒症
焦亡
炎症
Sepsis
Pyroptosis
Inflammation
