摘要
目的 本研究旨在探讨分析射频消融术治疗早期原发性肝癌的近远期疗效及血清miR-202水平的相关性。方法回顾性分析2010年1月至2013年12月68例早期原发性肝癌患者资料,患者均于我院接受射频消融术治疗。数据分析采用SPSS21.0统计学软件,治疗总有效率,5年生存率和复发率等计数资料则采用卡方检验;血清miR-202水平以(x±s)表示,采用t检验。P<0.05差异有统计学意义。结果经过射频消融术治疗后,完全缓解(CR)患者33例,部分缓解(PR)患者27例,疾病稳定(SD)患者6例,疾病进展(PD)患者2例,治疗总有效率为88.2%。患者的1年生存率为57例(83.8%),3年生存率为33例(48.5%),5年生存率为20例(29.4%),复发率35例(51.5%)。治疗前miR-202表达量(0.5±0.2),治疗后为(1.0±0.2),患者的血清miR-202水平较治疗前有明显升高(t=13.734,P=0.000);治疗后miR-202高表达组患者(40例)的近期疗效更好(P<0.05),5年生存率更高(P<0.05),术后复发患者数量更少(P<0.05)。结论早期原发性肝癌射频消融术治疗配合血清miR-202水平的检测,可以预测患者的近远期疗效,患者治疗后血清miR-202水平越高,生存时间越长,复发率越小。
Objective To investigate the short-term and long-term efficacy of radiofrequency ablation in the treatment of early primary liver cancer and the correlation of serum miR-202 levels. Methods Retrospective analysis of 68 patients with early primary liver cancer from January 2010 to December 2013, patients were treated with radiofrequency ablation in our hospital. SPSS21.0 statistics software was used for data analysis. The serum miR-202 level and other measurement data were expressed as (x±s) and compared with the independent t test. P <0.05 was statistically significant. Results After radiofrequency ablation, 33 patients with CR, 27 patients with PR, 6 patients with SD, and 2.9 patients with PD, the total effective rate was 88.2%. The 1-year survival rate was 57 (83.8%), the 3-year survival rate was 33 (48.5%), the 5-year survival rate was 20 (29.4%), and the recurrence rate was 35(51.5%). The serum miR-202 level of patients before treatment was(0.5±0.2) and after treatment was(1.0±0.2). After treatment was significantly higher than that before treatment (t=13.734, P =0.000). The short-term efficacy was better in patients with high expression of micro RNA-202 after treatment (40 cases)( P <0.05), the 5-year survival rate was higher ( P <0.05), and the number of patients with recurrence after operation was fewer ( P <0.05). Conclusion Serum miR-202 levels and radiofrequency ablation for the treatment of early primary liver cancer in the near-term and long-term efficacy are relevant, the higher the level of serum miR-202 after treatment, the better the efficacy in the near-term and long-term.
作者
李晓涛
Li Xiaotao(Department of hepatobiliary pancreaticobiliary surgery, Hanzhong city central hospital, Shanxi 723000)
出处
《中华普外科手术学杂志（电子版）》
2019年第3期250-252,共3页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
关键词
癌
肝细胞
消融技术
治疗结果
微RNAS
Carcinoma, hepatocellular
Ablation techniques
Treatment outcome
MicroRNAs
