摘要
目的:探究射频消融术对原发性肝癌患者肝功能、免疫功能及远期疗效的影响。方法:回顾性分析2017年1月—2019年6月于景德镇市第一人民医院进行治疗的78例原发性肝癌患者,依据手术方式不同分为切除组(n=39)、消融组(n=39)。切除组行腹腔镜肝切除术,消融组行射频消融术。比较两组围手术期指标、肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(STB)、结合胆红素(CB)]、免疫功能指标[T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))]水平,随访记录两组1、3年生存率。结果:消融组手术时间及住院时间均短于切除组,术中出血量少于切除组,差异均有统计学意义(P<0.05)。两组术后肝功能指标均有所降低,且消融组ALT、AST、STB、CB水平均显著低于切除组,差异均有统计学意义(P<0.05)。消融组术后CD3^(+)、CD4^(+)均明显高于切除组,CD8^(+)低于切除组,差异均有统计学意义(P<0.05)。两组术后1、3年生存率对比,差异均无统计学意义(P>0.05)。结论:射频消融术在原发性肝癌患者的治疗中应用效果显著,可减轻患者肝功能损伤,促进免疫功能恢复。
Objective:To explore the effects of radiofrequency ablation on liver function,immune function and long-term effect in patients with primary carcinoma of liver.Method:A total of 78 patients with primary carcinoma of liver treated in Jingdezhen NO.1 People's Hospital from January 2017 to June 2019 were retrospectively analyzed,and divided into resection group(n=39)and ablation group(n=39)according to different surgical methods.The resection group was performed laparoscopic hepatectomy,the resection group was performed radiofrequency ablation.Perioperative period indexes,liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum total bilirubin(STB),conjugated bilirubin(CB)]and immune function indexes[T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+))]of the two groups were compared,and the 1,3-year survival rates of the two groups were followed up and recorded.Result:The operative time and hospital stay in ablation group were shorter than those in resection group,and the intraoperative bleeding volume was less than that in resection group,the differences were statistically significant(P<0.05).After surgery,the liver function indexes in both groups were decreased,and the levels of ALT,AST,STB and CB in ablation group were significantly lower than those in resection group,the differences were statistically significant(P<0.05).After surgery,CD3^(+)and CD4^(+)in ablation group were significantly higher than those in resection group,and CD8^(+)in ablation group was lower than that in resection group,the differences were statistically significant(P<0.05).There were no significant differences in 1,3-year survival rates after surgery between the two groups(P>0.05).Conclusion:Radiofrequency ablation has a remarkable application effect in the treatment of patients with primary carcinoma of liver,which can reduce the liver function injury and promote the recovery of immune function.
作者
李泽灵
LI Zeling(Jingdezhen NO.1 People's Hospital,Jiangxi Province,Jingdezhen 333000,China)
出处
《中国医学创新》
CAS
2023年第30期15-18,共4页
Medical Innovation of China
关键词
原发性肝癌
射频消融术
肝功能
免疫功能
远期疗效
Primary carcinoma of liver
Radiofrequency ablation
Liver function
Immune function
Long-term effect
