摘要
目的运用静息态功能性磁共振成像(fMRI)技术研究针刺左侧支沟穴对健康人脑内左、右侧旁中央小叶(LPCG、RPCG)为种子点功能连接网络响应脑区在针刺前后不同时间序列内的差异。方法对18名健康受试者左前臂支沟穴进行fMRI扫描,包括:针刺前静息态扫描(R1)、留针期间扫描(R2～R5)和拔针后扫描(R6～R7),分别以LPCG、RPCG为种子点进行功能连接分析。结果①以LPCG为感兴趣区种子点,R2减R1功能连接差异脑区为双侧小脑后叶、左侧颞上回,R3减R1差异脑区为左侧中央后回、双侧额下回、右侧楔前叶,R4减R1差异脑区为右侧小脑后叶、左侧顶下小叶、左侧额下回,R5减R1差异脑区为左侧额下回,R6减R1差异脑区为左侧小脑后叶、右侧额内侧回、右侧额中回,R7减R1差异脑区为右侧小脑后叶、左侧额中回。②以RPCG为感兴趣区种子点,R2减R1差异脑区为左侧小脑后叶、双侧顶上小叶、双侧中央前回,R3减R1差异脑区为右侧梭状回、左侧楔前叶、右侧中央前回,R4减R1差异脑区为左侧中央前回,R5减R1差异脑区为右侧扣带前回,R6减R1差异脑区为左侧颞中回,R7减R1差异脑区为左侧中央前回。结论上述脑区与下肢感觉、运动功能及排尿、排便的中枢调控具有一定相关性,推测上述脑区与LPCG、RPCG所形成的随时间序列变化的功能连接网络是临床针刺支沟穴治疗下肢感觉、运动功能及二便排泄障碍的可能的中枢响应机制。
Objective To observe the difference changes of functional connectivity network of time-varying effect with left and right paracentral gyri as regions of interest. Methods Eighteen healthy participants were recruited in this trial. The scanning involved pure resting state(R1), acupuncture states(R2-R5) and withdrawing needle states(R6-R7). All scanning images were analyzed with functional connectivity method with left paracentral gyrus(LPCG) and right paracentral gyrus(RPCG) as regions of interest. Results ①Different altered regions of functional connectivity with LPCG as regions of interest followed by time-varying showed: bilateral posterior cerbellar lobe and left superior temporal gyrus under R2 subtract R1, left postcentral gyrus, bilateral inferior frontal gyrus and right praecuneus under R3 subtract R1, right posterior cerbellar lobe, left inferior parietal lobule and left inferior frontal gyrus under R4 subtract R1, left inferior frontal gyrus under R5 subtract R1, left posterior cerbellar lobe, right medial frontal gyrus and right medial frontal gyrus under R6 subtract R1, right posterior cerebellar lobe and left frontal gyrus under R7 subtract R1.②Different altered regions of functional connectivity with RPCG as regions of interest followed by time-varying showed: left posterior cerbellar lobe, bilateral superior parietal lobule and bilateral precentral gyrus under R2 subtract R1, right fusiform gyms and right precentral gyrus under R3 subtract R1, left precentral gyrus under R4 subtract R1, right anterior cingulate cortex under R5 subtract R1, left medial temporal gurus under R6 subtract R1, left precentral gyrus under R7 subtract R1. Conclusion Regions mentioned above were related to the sensation and motor functions of lower extremities and two bowel excretion. We speculated difference changes of functional connectivity network of time-varying effect with LPCY and RPCY as regions of interest is the central mechanism of acupuncture at TE6 for the treatment of disorder of sensation and motor functio
作者
韩红艳
段晓菡
王柯柯
王文献
张驰
高辉
闫镔
Han Hongyan;Duan Xiaohan;Wang Keke;Wang Wenxian;Zhang Chi;Gao Hui;Yan Bin(Department of Acupuncture Moxibustion and Tuina, Henan University of Chinese Medicine, Henan 450008, China;Chinese PLAInformation Engineering University, Henan 450001, China)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2019年第4期325-331,共7页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家重点研发计划项目(No.2017YFB1002502)
河南中医学院省属高校基本科研业务费项目(No.2014KYYWF-QN13)~~
关键词
支沟穴
针刺
旁中央小叶
功能连接
时变效应
TE6
acupuncture
paracentral gyri
functional connectivity
time-varying effect
