摘要
角膜内皮细胞(HCECs)是保证角膜透明的重要结构,在角膜后弹力层和前房之间,具有屏障和离子泵功能,防止前房房水进入角膜的同时又可以将角膜基质中的水分转移至前房,维持角膜正常厚度。当HCECs损伤、密度下降到一定程度时,这种平衡被打破,就会产生角膜水肿等角膜疾病。因此,HCECs在角膜组织解剖中的作用十分重要。此外,目前在体HCECs是不可再生的,一旦损害,视力将会严重受损。本文中笔者就HCECs的正常生理、损伤机制、检测、治疗及再生的研究情况进行综述。
The corneal endothelial cells (HCECs) are an important structure to ensure corneal transparency, with functions of barrier and ion pump between entocornea and anterior chamber which could prevent anterior chamber aqueous humor into cornea;at the same time, transfer moisture in the corneal stroma to the anterior chamber to maintaine normal thickness of cornea. HCECs once were damaged, can decrease their density to a certain extent. And with the unbalance going on, the disease could be with the symptom of corneal edema, etc. Therefore, HCECs play a extremely important role in corneal anatomy. Additionally, HCECs are non-renewable in vivo and serious loss of vision are non-recovered if damaged. This paper reviews the current status of the normal physiology, damage mechanism, detection, treatment, and regeneration of HCECs.
作者
苏冠羽
王乐滢
梁庆丰
Su Guanyu;Wang Leying;Liang Qingfeng(Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Keynote Laboratory of Ophthalmology and Visual Science, Beijing 100730, China)
出处
《中华眼科医学杂志（电子版）》
2019年第2期118-123,共6页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
基金
北京市卫生系统高层次卫生技术人才培养基金(2014-3-016)
国家重点研发计划项目(2017YFB1302703)
关键词
角膜内皮细胞
损伤机制
检测
治疗
再生
Human corneal endothelial cells (HCECs)
Damage mechanism
Detection
Treatment
Regeneration
