摘要
目的分析沙利度胺治疗强直性脊柱炎的有效性与安全性。方法选取我院2016年2月至2018年4月收治的80例活动期强直性脊柱炎患者为研究对象,将其随机分为对照组和观察组,各40例。对照组接受传统药物治疗,观察组在对照组基础上接受沙利度胺治疗。比较两组患者的治疗效果。结果观察组治疗总有效率明显高于对照组(P<0.05)。治疗后,两组的晨僵时间、外周关节肿痛数、枕壁试验结果、C反应蛋白水平和红细胞沉降率均显著改善,且观察组优于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率均为10.00%(4/40)。结论沙利度胺治疗强直性脊柱炎的临床效果显著,且安全性高,值得推广。
Objective To analyze the efficacy and safety of thalidomide in the treatment of ankylosing spondylitis.Methods Eighty patients of active ankylosing spondylitis admitted in our hospital from February 2016 to April 2018 were selected as the research objects and randomly divided into control group and observation group, with 40 cases in each group. The control group received traditional drug therapy. On the basis of the control group, the observation group was treated with thalidomide. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was significantly higher than that of the control group(P <0.05). After treatment, the morning stiffness time, number of peripheral joint swelling and pain, result of occipital wall test, c-reactive protein level and erythrocyte sedimentation rate of the two groups improved significantly, and those in the observation group were superior to the control group, with statistically significant differences(P<0.05). The total incidence of adverse reactions in both groups was 10.00%(4/40). Conclusion Thalidomide in the treatment of ankylosing spondylitis has a significant clinical effect and high safety, which is worthy of promotion.
作者
王喆
赵小莹
权柄涛
黄国强
WANG Zhe;ZHAO Xiao-ying;QUAN Bing-tao;HUANG Guo-qiang(Blood and Rheumatology Department,Hanzhong Central Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2019年第14期30-32,共3页
Clinical Research and Practice
