摘要
目的分析探讨养心通痹汤联合常规溶栓治疗对急性心肌梗死患者心肌缺血再灌注损伤指标的影响。方法按照随机数字表法将所有患者简单随机分为治疗组和对照组两组,所有患者均给予常规的溶栓治疗,治疗组患者则在此基础上联合使用中药养心痛痹汤进行治疗。记录两组患者治疗前后的肌酸激酶同工酶和肌酸激酶水平以及超敏C反应蛋白水平、高敏肌钙蛋白水平,比较两组患者治疗前后的左室射血分数和心肌梗死面积以及不良反应情况等。结果经过治疗后,两组患者的TNT-HS、CK-MB、CK、hs-CRP等水平均显著优于本组治疗前;治疗组患者治疗后的TNT-HS、CK-MB、CK、hs-CRP等水平均显著优于同期对照组患者。两组患者治疗1天后和治疗7天后的左室射血分数及心肌梗死面积均显著优于本组治疗前;治疗组患者治疗1天后和治疗7天后的左室射血分数均显著高于对照组患者;治疗组患者治疗1天后和治疗7天后的心肌梗死面积均显著低于对照组患者。治疗组患者的再灌注心律失常发生率和不良心血管事件发生率分别为6.67%和6.67%,分别低于对照组患者的26.27%和33.33%。结论对急性心肌梗死患者采用常规溶栓联合养心痛痹汤进行治疗能够有效改善其再灌注损伤情况,并且能够有效避免不良心血管事件的发生和促进患者左室射血功能的恢复,值得在临床上加以推广运用。
Objective: To explore the effect of Yangxin Tongbi Decoction combined with routine thrombolytic therapy on myocardial ischemia-reperfusion injury index in patients with acute myocardial infarction. Methods: According to the random number table method, all patients were randomly divided into treatment group and control group. All patients were given routine thrombolytic therapy, while patients in treatment group were treated with Yangxi Tongbi Decoction additionally. The levels of creatine kinase isoenzymes and creatine kinase, hypersensitive C-reactive protein and hypersensitive troponin were recorded before and after treatment. Left ventricular ejection fraction, myocardial infarction area and adverse reactions were compared between the two groups before and after treatment.Results:After treatment, the levels of TNT-HS, CK-MB, CK, hs-CRP in the two groups were significantly better than those before treatment;the levels of TNT-HS, CK-MB, CK, hs-CRP in the treatment group were significantly better than those in the control group. The left ventricular ejection fraction and myocardial infarction area of the two groups after 1 day and 7 days of treatment were significantly better than those before treatment;the left ventricular ejection fraction of the treatment group was significantly higher than that of the control group after 1 day of treatment and 7 days of treatment;the myocardial infarction area of the treatment group was significantly lower than that of the control group after 1 day of treatment and 7 days of treatment. The incidence of reperfusion arrhythmia and adverse cardiovascular events in the treatment group were 6.67% and 6.67%, respectively, lower than those in the control group(26.27% and 33.33%). Conclusion:Conventional thrombolysis combined with Yangxin Tongbi Decoction can effectively improve the reperfusion injury in patients with acute myocardial infarction, and can effectively avoid adverse cardiovascular events and promote the recovery of left ventricular ejection function. It is worth popular
作者
闫明霞
Yan Mingxia(Shanyang TCM Hospital, Shanyang Shaanxi ,726400)
出处
《现代中医药》
CAS
2019年第3期38-41,共4页
Modern Chinese Medicine
关键词
急性心肌梗死
心肌缺血
再灌注损伤
养心痛痹汤
溶栓治疗
acute myocardial infarction
myocardial ischemia
reperfusion injury
Yangxin Tongbi Decoction
thrombolytic therapy
