摘要
目的探讨缺血性小卒中患者两年复发卒中的危险因素。方法纳入我院神经内科2013年1月~2015年1月入院确诊为缺血性小卒中患者474例,共随访两年,以脑卒中复发为终点访视事件。收集复发及未复发患者各项临床资料,采用Log-rank检验进行单因素分析,Cox回归模型进行多因素分析。结果两年内复发缺血卒中患者68例,复发率为14.35%。多因素Cox回归分析结果显示年龄≥65岁(HR 1.877,95%CI 1.159~3.072,P=0.011)、既往脑卒中或短暂性脑缺血发作(transient ischemic attack,TIA)史(HR1.851,95%CI 1.096~3.126,P=0.021)、糖尿病(HR 2.186,95%CI 1.350~3.541,P=0.001)、大动脉狭窄(HR1.789,95%CI 1.079~2.966,P=0.024)是缺血性小卒中两年内再发脑卒中的危险因素。结论年龄≥65岁、既往脑卒中或TIA史、糖尿病、大动脉狭窄是影响缺血性小卒中复发的危险因素,给予合理正确的二级预防,可以减少卒中复发。
Objective To explore the risk factors for recurrent stroke in patients with minor ischemic stroke within two years. Methods 474 patients who were diagnosed minor ischemic stroke in our hospital from January 2013 to January 2015 were selected, they were followed up for two years, the recurrence of stroke were as endpoint visit events. Clinical data of relapsed and non-relapsed patients were collected. Log-rank test was used for univariate analysis and Cox regression model was used for multivariate analysis. Results 68 cases was recurrent ischemic stroke within two years, the recurrence rate was 14.35%. Multivariate Cox regression analysis showed that age ≥ 65 years old(HR 1.877,95%CI 1.159-3.072, P=0.011), past stroke or transient ischemic attack(TIA) history(HR 1.851,95%CI1.096-3.126,P=0.021), diabetes mellitus(HR 2.186,95%CI 1.350-3.541,P=0.001)and large artery stenosis(HR1.789,95%CI 1.079-2.966,P=0.024)were the risk factors for recurrent stroke within two years after minor ischemic stroke. Conclusion Age ≥ 65 years old, past stroke or TIA history, diabetes mellitus and large artery stenosis are the risk factors for recurrence of minor ischemic stroke. Reasonable and correct secondary prevention can reduce recurrence of stroke.
作者
游文霞
钟剑萍
黄美媚
侯蕴祈
刘健
黎宏庄
杨少民
胡秋根
YOU Wenxia;ZHONG Jianping;HUANG Meimei;HOU Yunqi;LIU Jian;LI Hongzhuang;YANG Shaomin;HU Qiugen(Neurology Department, Shunde Hospital of Southern Medical University,the First People's Hospital of Shunde, Foshan 528308, China;Radiological Department, Shunde Hospital of Southern Medical University,the First People's Hospital of Shunde,Guangdong, Foshan 528308, China)
出处
《中国医药科学》
2019年第10期11-14,46,共5页
China Medicine And Pharmacy
基金
广东省佛山市卫生和计划生育局医学科研立项课题(20180347)
广东省佛山市科技创新项目(医学科技创新平台)(佛科公示[2018]11号-16)
关键词
缺血性脑卒中
小卒中
复发
危险因素
Cerebral arterial thrombosis
Minor stroke
Recurrence
Risk factor