摘要
目的:探讨累积吸烟暴露量对非肌层浸润性膀胱癌(non-muscle invasive bladder cancer,NMIBC)患者预后的影响。方法:选取2010年1月至2013年8月在宜宾市第一人民医院泌尿外科行经尿道膀胱肿瘤电切术(transurethral resection of bladder tumor,TURBT)的NMIBC患者142例为研究对象。收集患者临床病理资料及吸烟情况。采用Kaplan-Meier法分析累积吸烟暴露量与术后肿瘤复发的关系。采用COX风险回归模型分析影响NMIBC患者预后的独立危险因素。结果:142例NMIBC患者术后平均随访时间为(35.71±16.96)个月;低暴露量组和高暴露量组肿瘤复发例数分别为24例和45例,高暴露量组肿瘤复发率高于低暴露量组(P<0.05);Kaplan-Meier法分析显示,高暴露量组肿瘤无复发累积生存率低于低暴露量组(P=0.002);COX风险回归模型分析显示,累积吸烟暴露量为NMIBC患者独立预后因素(P<0.05)。结论:高累积吸烟暴露量可增加NMIBC患者的肿瘤复发风险。
Objective:To explore the effect of cumulative exposure to smoking on prognosis of patients with non-muscle invasive bladder cancer(NMIBC).Methods:From January 2010 to August 2013,142 patients with NMIBC who underwent transurethral resection of bladder tumor(TURBT) in the urology department of the First People’s Hospital of Yibin were selected as subjects.Clinical and pathological data and smoking status were collected.Kaplan-Meier method was used to analyze the relationship between cumulative exposure to smoking and postoperative tumor recurrence.COX risk regression model was used to analyze the independent risk factors affecting the prognosis of NMIBC patients.Results:The average follow-up time of 142 NMIBC patients was(35.71±16.96) months.The number of recurrence cases in low exposure group and high exposure group were 24 cases and 45 cases respectively.The recurrence rate of high exposure group was higher than that of low exposure group(P<0.05).Kaplan-Meier analysis showed that recurrence free cumulative survival rate in the high exposure group was lower than in the low exposure group(P<0.05).The COX risk review model showed that cumulative exposure to smoking was an independent prognostic factor for NMIBC patients(P<0.05).Conclusion:High cumulative exposure to smoking can increase the risk of tumor recurrence in NMIBC patients.
作者
钱文燕
杨宇
Qian Wenyan;Yang Yu(Department of Urology Surgery,the First People's Hospital of Yibin,Sichuan Yibin 664000,China)
出处
《现代肿瘤医学》
CAS
2019年第12期2143-2146,共4页
Journal of Modern Oncology
基金
宜宾市卫生和计划生育委员会科研项目(编号:2017734-04)
关键词
累积吸烟暴露量
吸烟指数
非肌层浸润性膀胱癌
预后
cumulative exposure to smoking
smoking index
non-muscle invasive bladder cancer
prognosis
