摘要
目的探究磷酸肌酸钠对新生儿窒息后心肌损伤的治疗效果。方法选择2016年2月至2018年2月在自贡市妇幼保健院产科出生的184例窒息新生儿为研究对象,采用随机数表法将其分为对照组和观察组,每组各92例,对照组患儿采取新生儿窒息后常规治疗手段,观察组患儿在对照组基础上加用磷酸肌酸钠治疗,观察两组患儿治疗前后血管内皮生长因子(vascular endothelial growth factor,VEGF)、热休克蛋白(heat shock protein,HSP)70、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB)、肌钙蛋白T(troponin T,cTnT)水平及循环改善情况,比较两组患儿治疗后心功能指标和治疗效果。结果治疗前两组患儿VEGF、HSP70、CK-MB、cTnT水平均无明显差异(P_均> 0.05),治疗后VEGF、CK-MB、cTnT水平均明显下降(P_均<0.05),HSP70水平均明显上升(P <0.05),但观察组患儿VEGF、CK-MB、cTnT水平均明显低于对照组(P_均<0.05),HSP70水平高于对照组(P <0.05)。两组患儿治疗前心率(heart rate,HR)、呼吸频率(respiratory rate,RR)、血氧饱和度(oxygen saturation,SpO_2)均无明显差异(P_均> 0.05),治疗后HR、RR较治疗前均明显下降(P_均<0.05),SpO_2较治疗前均明显升高(P_均<0.05),观察组患儿RR、HR、SpO_2改善情况均显著优于对照组(P_均<0.05)。治疗后,观察组患儿心电图异常率及左心室射血分数、脑钠肽水平均明显低于对照组(P_均<0.05),治疗显效率和有效率均明显高于对照组(P_均<0.05)。结论磷酸肌酸钠治疗新生儿窒息后心肌损伤疗效显著,可将其作为治疗新生儿窒息后心肌损伤的临床用药。
Objective To explore the efficacy of sodium creatine phosphate in the treatment of cardiac injury in neonates with asphyxia.Method 184 cases of asphyxia newborn born in Zigong City Maternal and Child Health Hospital from February 2016 to February 2018 were selected as subjects.They were divided into control group and observation group by random number table method 92 cases in each group.Children in control group received conventional treatment after neonatal asphyxia.Children in observation group received intravenous infusion of sodium creatine phosphate on the basis of control group.Vascular endothelial growth factor(VEGF),heat shock protein(HSP)70,and creatine kinase isoenzymes(CK-MB),troponin T(cTnT)levels and circulatory improvement before and after treatment were observed in the two groups,and cardiac function indexes and therapeutic effects were compared between the two groups after treatment.Result There were no significant differences in VEGF,HSP70,CK-MB and cTnT levels between the two groups before treatment(Pall>0.05).After treatment,the levels of VEGF,CK-MB and cTnT were significantly decreased in the two groups(Pall<0.05),and the level of HSP70 was significantly increased(P<0.05).However,VEGF,CKMB and cTnT levels in observation group were significantly lower than those in control group(Pall<0.05),and HSP70 levels were significantly higher than those in control group(P<0.05).The heart rate(HR),respiratory frequency(RR),oxygen saturation(SpO2)between the two groups before treatment had no obvious difference(Pall>0.05).After treatment,HR and RR were significantly lower than before treatment(Pall<0.05),SpO2 was significantly higher than before treatment(Pall<0.05).The improvement of RR,HR and SpO2 in observation group was better than that in control group(Pall<0.05).After treatment,the electrocardiogram abnormality rate and left ventricular ejection fraction(LVEF),brain natriuretic peptide(BNP)levels were significantly lower than control group(Pall<0.05).The treatment efficiency and effective rate in obse
作者
张晓晴
杜逸亭
ZHANG Xiao-qing;DU Yi-ting(Department of Neonatology,Zigong City Maternal and Child Health Hospital,Sichuan,Zigong 643010,China;Department of Neonatology,Chengdu Women and Children's Center Hospital,Chengdu 610091,China)
出处
《中国医学前沿杂志（电子版）》
2019年第4期97-100,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
四川省卫生和计划生育委员会科研课题(201508540)
关键词
磷酸肌酸钠
新生儿窒息
血管内皮生长因子
热休克蛋白70
肌酸激酶同工酶
肌钙蛋白T
Sodium creatine phosphate
Neonatal asphyxia
Vascular endothelial growth factor
Heat shock protein 70
Creatine kinase isoenzymes
Troponin T
