摘要
目的分析、阐述镇痛镇静治疗ICU重症脓毒血症患者,总结其治疗效果。方法方便选取2016年5月—2017年5月该院收治的30例患者为研究对象,将其划分为观察组与对照组。对照组使用单一吗啡缓释片治疗,观察组使用枸椽酸芬太尼联合米达唑仑注射液治疗。观察两组患者临床治疗效果,包括:镇静效果、唤醒时间、治疗前后血液流变指标、治疗有效率。结果两组患者镇静效果对比,观察组镇静时间为(96.22±11.15)min,对照组镇静时间为(81.38±10.33)min(t=10.70,P=0.00);唤醒时间对比观察组唤醒时间为(122.42±22.37)min,对照组唤醒时间为(95.41±20.21)min(t=19.46,P=0.00);两组患者治疗前后血液流变检测指标对比、两组患者镇痛评分对比、两组患者治疗总有效率对比。观察组明显优于对照组,组间数据差异有统计学意义(χ~2=4.66,P=0.03<0.05)。结论枸椽酸芬太尼联合米达唑仑注射液治疗ICU重症脓毒血症患者,可改善患者临床治疗效果,降低治疗过程中手术与疾病带来的不良情绪与心理因素,全面提升治疗有效率。枸椽酸芬太尼联合米达唑仑注射液相比单一的硫酸吗啡缓释片镇痛效果更佳,其药用价值显著,值得大面积推广应用。
Objective To analyze and elaborate the analgesic and sedative treatment of severe sepsis patients in ICU,and summarize its therapeutic effect.Methods Thirty patients admitted to our hospital from May 2016 to May 2017 were convenient selected and divided into observation group and control group.The control group was treated with morphine sustained-release tablets and the observation group with fentanyl citrate combined with midazolam injection.The clinical therapeutic effects of the two groups were observed,including sedation effect,wake-up time,hemorheological index before and after treatment,and effective rate.Results The sedative effect of the two groups was compared.The sedation time of the observation group was(96.22±11.15)min,and the sedation time of the control group was(81.38±10.33)min(t=10.70,P=0.00).The wake-up time comparison observation group wake-up time was(122.42±22.37)min,the wake-up time of the control group was(95.41±20.21)min(t=19.46,P=0.00);the blood rheology test indexes before and after treatment in the two groups,the analgesic scores of the two groups,and the total effective rate of treatment for patients.The observation group was significantly better than the control group,and the data difference between the groups was statistically significant(χ^2=4.66,P=0.03<0.05).Conclusion The combination of fentanyl citrate and midazolam in the treatment of patients with severe sepsis in ICU can improve the clinical treatment effect of patients,reduce the negative emotional and psychological factors brought about by surgery and disease during treatment,and improve the treatment efficiency.Compared with a single morphine sulfate sustained-release tablet,fentanyl citrate combined with midazolam injection has better analgesic effect,and its medicinal value is significant,which is worthy of widespread application.
作者
孔杰
KONG Jie(Department of ICU,People's Hospital of Qufu City,Qufu,Shandong Province,273100 China)
出处
《中外医疗》
2019年第9期7-10,共4页
China & Foreign Medical Treatment
