摘要
桥粒芯蛋白(DSG)是细胞间紧密连接结构之一桥粒的重要组成蛋白,为单次跨膜糖蛋白,与桥粒胶蛋白相互结合,具有调节细胞间黏附、传递胞内外信号等作用。已有研究表明DSG亚型之一DSG2在肿瘤细胞中异常表达,并对肿瘤的靶向治疗及预后有一定价值。文章主要就DSG2蛋白的结构、生物学功能以及相关疾病等进行综述。
Desmoglein(DSG)is an important constituent of desmosome,a single transmembrane glycoprotein that binds to desmocollin(DSC),regulates intercellular adhesion and transmits intracellular and extracelluar signals. Studies have shown that DSG2,one subtype of the DSG,is abnormally expressed in tumor cells and has certain value for targeted treatment and prognosis. This paper reviews the structure,biological functions and related diseases of DSG2 protein.
作者
杨婷婷
唐奇
冯振卿
YANG Ting-ting;TANG Qi;FENG Zhen-qing(Basic Medical College,Nanjing Medical University,Nanjing 211166,Jiangsu,China;Key Laboratory of Antibody Technique of National Health Commission / Jiangsu KeyLaboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for CancerPersonalized Medicine,Nanjing Medical University,Nanjing 211166,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第5期540-545,共6页
Journal of Medical Postgraduates
基金
国家自然科学基金(81773100)
