摘要
趋化因子(chemoattractant cytokine ligand,CCL)是一类可趋化细胞移动的小分子肽物质,根据其分子结构中N-末端半胱氨酸的相对位置主要分为四种类型,CCL17是其中CC型的趋化因子,也被称作胸腺和活化调节趋化因子(thymus and activation regulated chemokine,TARC).趋化因子通过结合细胞表面的趋化因子受体(chemokine receptor,CCR)发挥其生物学功能,CCL17对应的膜受体为CCR4分子,主要表达于多种T淋巴细胞亚群的细胞膜表面.研究发现CCL17具有多样的生物学功能,它能够趋化CCR4阳性的细胞发生迁移作用,参与到机体的炎症、超敏反应及自身免疫性疾病等多种病理生理过程,近年来有关CCL17参与肿瘤微环境及影响机体肿瘤免疫功能的研究多有报道,研究发现CCL17可能通过调节性T细胞(regulatory T cells,Treg)发挥促进肿瘤生长与转移的作用,但也有相关报道证实CCL17在特定条件下亦具有抗肿瘤免疫作用.
Chemokines are a family of small molecule peptides that can induce the cells of migration. According to the relative position of the N-terminal cysteine in its molecular structure,it is mainly divided into four types. Chemoattractant cytokine ligand(CCL)17 is a type of CC-type chemokine,also known as thymus and activation regulated chemokine( TARC). Chemokines exert biological functions through chemokine receptors (CCR)on the cell surface. The membrane receptor corresponding to CCL17 molecule is CCR4,which is mainly expressed on the cell membrane surface of various T lymphocyte subsets. The study found that CCL17 has di-verse biological functions,which can chemotaxis of CCR4-positive cells. CCL17 is involved in various pathologi-cal and physiological processes such as inflammation,hypersensitivity and autoimmune diseases in the body. In recent years,it has been reported that CCL17 participates in tumor microenvironment and affects tumor immune function. Studies have found that CCL17 may play a role in promoting tumor growth and metastasis through regu-latory T cells,but there are also reports that CCL17 also has anti-tumor immunity under specific conditions.
作者
王悦
陈桂思
邵红伟
沈晗
Wang Yue;Chen Guisi;Shao Hongwei;Shen Han(Biotechnology Drug Candidates, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University,Guangzhou 510006, China)
出处
《国际免疫学杂志》
CAS
2019年第2期175-179,共5页
International Journal of Immunology
基金
国家自然科学基金(31300737)
广东省科技计划项目(2014A020212311)
广东省自然科学基金(2018A030313114).
