期刊文献+

重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白对强直性脊柱炎患者疗效及炎症因子、脊柱活动度的影响 被引量:9

Effect of recombinant human tumor necrosis factor receptor-fc fusion protein on inflammatory factors and spinal activity of patients with ankylosing spondylitis
下载PDF
导出
摘要 目的探讨重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白(rhTNFR:Fc)对强直性脊柱炎(AS)患者疗效及炎症因子、脊柱活动度的影响。方法纳入2015-02-2017-02,于我院治疗的76例AS患者,随机均分为观察组与对照组各38例。对照组患者给予甲氨蝶呤、柳氮磺吡啶治疗,观察组在此基础上联合rhTNFR:Fc皮下注射,连续治疗3个月。比较两组治疗前后血清肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)等炎性因子水平、chober试验、颈部旋转等脊柱活动度指标以及脊柱疼痛、关节肿胀等症状指标,评价治疗3各月后综合疗效并记录不良反应发生情况。结果两组治疗后,血清TNF-α、CRP、白细胞介素6(IL-6)、IL-8水平均显著降低,且治疗后观察组显著低于对照组,差异有统计学意义(P<0.05);两组治疗后chober试验、颈部旋转、腰椎侧弯、扩胸度均显著增加,且治疗后观察组显著高于对照组,差异有统计学意义(P<0.05);两组治疗后AS病情活动指数(BASDAI)、晨僵时间、脊柱疼痛评分均显著降低,且治疗后观察组显著低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为89.47%,显著高于对照组的76.32%,差异有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 rhTNFR:Fc皮下注射联合甲氨蝶呤、柳氮磺吡啶治疗AS,能显著改善患者临床症状及脊柱活动度,降低炎症反应,治疗安全有效。 Objective To investigate the effect of recombinant human tumor necrosis factor receptor-Fc fusion protein (rhTNFR: Fc) on inflammatory factors and spinal activity of patients with ankylosing spondylitis (AS). Methods 76 cases of AS patients treated in our hospital from February 2015 to February 2017 were selected and equally divided into two groups. The control group received the methotrexate and sulfasalazine, based on this, the observation group received the subcutaneous injection of rhTNFR:Fc, lasting for 3 months. The levels of inflammatory factors such as TNF-alpha, CRP, chober test, cervical rotation and symptoms such as spinal pain and joint swelling were compared between the two groups before and after treatment. The comprehensive curative effect after 3 months of treatment was evaluated and the occurrence of adverse reactions was recorded. Results Serum levels of TNF-α, CRP, interleukin-6 (IL-6) and IL-8 were significantly decreased after treatment, and were lower in the observation group than in the control group (P< 0.05);The chober test, neck rotation, lumbar scoliosis, and chest enlargement were significantly increased after treatment in both groups, and were higher in the observation group than in the control group (P<0.05);The AS disease activity index (BASDAI), morning stiffness time, and spinal pain score were significantly decreased after treatment, and were lower in the observation group than in the control group (P<0.05);The total clinical efficacy rate of the observation group was higher than that of the control group (89.47% vs 76.32%, P<0.05). The incidence of adverse reactions between the two groups had no difference (P>0.05). Conclusion The subcutaneous injection of rhTNFR:Fc combined with methotrexate and sulfasalazine is an effective and safe way to ameliorate the clinical symptoms and spinal mobility, reduce inflammation in the treatment of AS.
作者 陈栋 孙伟 CHEN Dong;SUN Wei(Department of Orthopedics,Sino -Japanese Friendship Hospital;Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing,100000,China)
出处 《颈腰痛杂志》 2019年第2期145-148,共4页 The Journal of Cervicodynia and Lumbodynia
基金 国家自然科学基金项目(批准号:81871830)
关键词 重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白 强直性脊柱炎 疗效 炎症因子 活动度 rhtnfr:fc as effect inflammatory factor spinal activity
  • 相关文献

参考文献9

二级参考文献62

  • 1王庆文,曾庆馀,肖征宇,陈肃标,刘源,吴名耀.脊柱关节病患者骶髂关节细针活检的病理表现及其临床意义[J].中华内科杂志,2004,43(11):832-836. 被引量:41
  • 2黄建敏,潘莉萍,李冬雪,吴炜杰,李会春.^(99)Tc-MDP治疗强直性脊柱炎的疗效观察[J].中华核医学杂志,2005,25(3):174-175. 被引量:22
  • 3叶志中,庄俊汉,汪迅,李剑松,张丽君.深圳市3个社区5922名居民强直性脊柱炎的流行病学调查(英文)[J].中国临床康复,2006,10(28):159-161. 被引量:8
  • 4胥少汀,葛宝丰,徐印坎,等.实用骨科学[M].第4版,人民军医出版社,2012.1644-1651. 被引量:2
  • 5Rudwaleit M,Metter A,Listing J. Inflammatory back pain in ankylosing spondylitis:a reassessment of the clinical history for application as classification and diagnostic criteria[J].{H}ARTHRITIS AND RHEUMATISM,2006.569-578. 被引量:1
  • 6Spoorenberg A,van Tubergen A,Landewé R. Measuring disease activity in ankylosing spondylitis:patient and physician have different perspectives[J].{H}Rheumatology(Oxford),2005.789-795. 被引量:1
  • 7Wang NS. Ankylosing Spondylitis[M].Shanghai:Shanghai Jiao Tong University Press,2009.86-88. 被引量:1
  • 8Francois RJ,Gardner DL,Degrave EJ. Histopathologic evidence that sacroilitis in ankylosing spondylitisis not merely enthesitis[J].{H}ARTHRITIS AND RHEUMATISM,2000.2011-2024. 被引量:1
  • 9Garrett S,Jenkinson T,Kennedy LG. A new approach to defining disease status in ankylosing spondylitis:the bath ankylosing spondylitis disease activity index (BASDAI)[J].{H}Journal of Rheumatology,1994.2286-2291. 被引量:1
  • 10BlumA,Roch D,Loeuille D. Bone marrow edema:definition,diagnostic value and prognostic value[J].{H}JOURNAL DE RADIOLOGIE,2009.1789-1811. 被引量:1

共引文献921

同被引文献83

引证文献9

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部