摘要
探讨缺氧诱导因子α(HIF-1α)、骨桥蛋白(OPN)在直肠癌组织中的表达及其临床意义。选取2014年6月至2017年6月该院收治的直肠癌患者160例,采用免疫组织化学(SP)法检测直肠癌及其癌旁正常组织中HIF-1α、OPN表达情况,分析两者与直肠癌病理特征及生存预后的关系。直肠癌组织中HIF-1α、OPN阳性表达率明显高于癌旁正常组织,差异有统计学意义(P <0. 05);单因素分析结果显示,HIF-1α、OPN在直肠癌组织中的阳性表达与淋巴结转移、Dukes分期、浸润深度有关(P <0. 05),但与性别、年龄、肿瘤直径、分化程度等无关(P> 0. 05);生存曲线分析结果显示,HIF-1α、OPN阳性表达患者1年生存率明显低于HIF-1α、OPN阴性表达患者,差异有统计学意义(P <0. 05)。HIF-1α、OPN与直肠癌的发生发展有关,提示检测两者表达可作为评估直肠癌生物学特性及生存预后的重要指标,值得临床推广。
To discuss the expression of hypoxia-inducible factor-1α(HIF-1α)and osteopontin(OPN)in rectal cancer and its clinical significance,160 patients with rectal cancer were selected from June 2014 to June 2017 in Zhengding hospital;the immunohistochemistry(SP)was used to detect the expression of HIF-1αand OPN in rectal cancer and its adjacent normal tissues.The relationship between the expression of HIF-1αand OPN and the pathological features and survival prognosis of rectal cancer were analyzed.The positive rates of HIF-1αand OPN in rectal cancer tissues were significantly higher than those in adjacent normal tissues and the difference was statistically significant(P<0.05).The Univariate analysis results showed that,the positive expressions of HIF-1αand OPN in rectal cancer tissues were related to lymph node metastasis,Dukes stage and depth of invasion(P<0.05),but they were not related to sex,age,tumor diameter and degree of differentiation(P>0.05).Survival curve analysis results showed that,the 1-year survival rate of patients with positive expression of HIF-1αand OPN were significantly lower than those of patients with negative expression of HIF-1αand OPN and the difference was statistically significant(P<0.05).The expression of HIF-1αand OPN was correlated with the occurrence and development of rectal cancer,suggesting that the detection of their expression may be the important index for evaluating the biological characteristics and survival and prognosis of rectal cancer.It is worth for further clinical promotion.
作者
翟雨佳
ZHAI Yu-jia(Department of Pathology,Zhengding County People's Hospital,Zhengding 050800,China)
出处
《药物生物技术》
CAS
2019年第1期45-48,共4页
Pharmaceutical Biotechnology
关键词
缺氧诱导因子α
骨桥蛋白
直肠癌
表达
病理特征
生存预后
Hypoxia-inducible factor-1α
Osteopontin
Rectal cancer
Expression
Pathological features
Survival prognosis
