摘要
目的探讨肺癌患者血清骨桥蛋白(OPN)、腺苷激酶1(TK1)和分泌型蛋白Dikkopf1(DKK1)的表达水平及其临床意义。方法选取2017年2月至2018年4月在西安医学院第一附属医院接受治疗的肺癌患者60例(肺癌组),以同期接受体检的60名健康成年人作为健康对照。比较肺癌组和健康对照组间、不同临床病理特征肺癌患者间血清OPN、TK1和DKK1水平的差异。两组间计量资料比较采用t检验。结果肺癌组患者血清OPN、TK1和DKK1水平分别为(38.56±3.18)μg/L、(4.69±1.03)pmol/L、(3.76±0.89)ng/ml,均分别高于健康对照组的(15.98±2.06)μg/L、(1.01±0.22)pmol/L、(1.21±0.24)ng/ml(t值分别为-46.162、-27.064、-21.428,均P<0.01)。不同年龄和性别的肺癌患者血清OPN、TK1和DKK1水平差异均无统计学意义(均P>0.05);Ⅲ~Ⅳ期肺癌患者血清OPN、TK1和DKK1水平分别为(57.18±3.12)μg/L、(6.26±1.28)pmol/L和(4.98±1.03)ng/ml,均高于Ⅰ~Ⅱ期肺癌患者的(30.35±2.96)μg/L、(3.49±0.67)pmol/L、(3.01±0.96)ng/ml(t值分别为-34.156、-10.690、-7.665,均P<0.01)。非小细胞肺癌患者血清OPN、TK1和DKK1水平分别为(55.13±5.02)μg/L、(5.96±1.11)pmol/L、(5.02±1.32)ng/ml,均高于小细胞肺癌患者的(29.68±3.16)μg/L、(3.13±0.98)pmol/L、(2.86±0.56)ng/ml(t值分别为-22.353、-10.213、-7.688,均P<0.01)。结论肺癌患者血清OPN、TK1和DKK1水平较高,且其水平与肺癌分型和分期有关。
Objective To observe the expression levels of serum osteopontin (OPN), adenosine kinase 1 (TK1) and secretory protein Dikkopf 1 (DKK1) in patients with lung cancer and their clinical significances. Methods Lung cancer patients treated in the First Affiliated Hospital of Xi'an Medical University from February 2017 to April 2018 were selected as the lung cancer group (60 cases), and 60 healthy adults who received physical examination in the same period were selected as the control group. The differences of serum OPN, TK1 and DKK1 levels between the lung cancer group and the control group and lung cancer patients with different characteristics were compared. Measurement data were compared by using t test. Results The levels of serum OPN, TK1 and DKK1 in lung cancer patients were (38.56±3.18)μg/L,(4.69±1.03) pmol/L and (3.76±0.89) ng/ml, respectively, which were higher than those in the control group [(15.98±2.06)μg/L,(1.01±0.22)pmol/L,(1.21±0.24) ng/ml;t=-46.162,-27.064,-21.428, all P < 0.01]. The levels of serum OPN, TK1 and DKK1 in lung cancer patients of different ages and gender had no statistical differences (all P > 0.05). The levels of serum OPN, TK 1 and DKK1 in stage Ⅲ-Ⅳ lung cancer patients were (57.18 ±3.12)μg/L,(6.26±1.28) pmol/L and (4.98±1.03) ng/ml, respectively, which were higher than those in stage Ⅰ-Ⅱ lung cancer patients [(30.35±2.96)μg/L,(3.49±0.67) pmol/L,(3.01±0.96) ng/ml;t=-34.156,-10.690,-7.665, all P < 0.01]. The levels of serum OPN, TK 1 and DKK1 in non-small cell lung cancer (NSCLC) patients were (55.13±5.02)μg/L,(5.96±1.11) pmol/L and (5.02±1.32) ng/ml, respectively, which were higher than those in small cell lung cancer (SCLC) patients [(29.68±3.16)μg/L,(3.13±0.98) pmol/L,(2.86±0.56) ng/ml;t =-22.353,-10.213,-7.688, all P < 0.01]. Conclusion The levels of serum OPN, TK1 and DKK1 in patients with lung cancer are higher, which are related to the type and stage of lung cancer.
作者
吴树强
廖和和
王甲林
任明智
黄慧云
赵朝华
Wu Shuqiang;Liao Hehe;Wang Jialin;Ren Mingzhi;Huang Huiyun;Zhao Zhaohua(Department of Oncology Surgery Thoracic, the First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China;No.215 Hospital of Shaanxi Nuclear Industry, Medical Center of Oncology, Xianyang 712021, China;Teaching and Research Room of Anatomy, School of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China)
出处
《肿瘤研究与临床》
CAS
2019年第3期149-153,共5页
Cancer Research and Clinic
基金
陕西省自然科学基础研究计划(2018JM7065)
陕西省教育厅科研计划(16JK1645).
