摘要
细菌活载体疫苗是指将某一病原体的特定抗原基因插入到细菌基因组或其质粒,然后在其增殖过程中直接表达外源抗原或将携带的外源DNA递呈到宿主细胞的一类重组细菌。细菌活载体疫苗能够诱导机体产生粘膜免疫、体液免疫和细胞免疫,是目前传染病预防控制、肿瘤免疫治疗、免疫调节等方面的重要研究方向之一。从细菌活载体疫苗的构建及应用两个方面进行介绍,以期为细菌活载体疫苗的研究与应用提供参考。
The bacteria engineered to deliver plasmids or carry heterologous gene which were also called live bacterial vector could stimulate the host’s broad-based immune system by expressing heterologous antigen, while still offering good levels of safety. The live bacterial vector vaccines which have become a trend in the development of biological products industry are promising candidates for plague prevention and tumor immunotherapy. Genetic technologies are evolving, which potentiate the development of the live bacterial vector vaccines. There is a brief overview of the construction, characteristics and the research status of live bacterial vaccine vector.
作者
倪志远
蒋桃珍
NI Zhi-yuan;JIANG Tao-zhen(China Institute of Veterinary Drug Control,Beijing 100081,China)
出处
《中国兽药杂志》
2019年第4期72-76,共5页
Chinese Journal of Veterinary Drug
关键词
细菌活载体疫苗
免疫应答
研究进展
live bacterial vector vaccine
immune response
research status
