摘要
目的:探讨过夜培养对不同质量冻融胚胎、囊胚治疗结局的影响。方法:回顾性分析大理大学第一附属医院开展的1 326个冻融胚胎移植(FET)周期的患者资料。根据实验目的,分为过夜培养组和常规培养组,对比分析两组间优质胚胎、非优质胚胎、优质囊胚、非优质囊胚移植患者的临床妊娠率。结果:优质胚胎、非优质囊胚移植患者的临床妊娠率在两组间差异无统计学意义(P>0.05)。过夜培养组非优质胚胎移植患者的临床妊娠率显著高于常规培养组(36.36%vs. 25.89%,P=0.021),而过夜培养组优质囊胚移植患者的临床妊娠率显著低于常规培养组(51.25%vs. 65.13%,P=0.040)。结论:过夜培养有利于改善非优质冻融胚胎的治疗结局,而不利于优质冻融囊胚的治疗。
Objective: To explore the effect of overnight incubation culture on the treament of different quality frozen-thawed-embryo and blastocyst. Methods: We retrospectively analyzed the patient data of 1 326 FET cycles conducted in the First Affiliated Hospital of Dali University. They were divided into the group of overnight incubation culture and the group of conventional culture according to the purpose of the study. We compared the difference of the clinic pregnancy rates of the patients respectively transferred good-quality embryo, non-good-quality embryo, good-quality blastocyst and non-good-quality blastocyst between two groups. Results: There were no differences of the clinic pregnancy rates of patients transferred the good-quality embryo or non-good-quality blastocyst between two groups. However, the clinic pregnancy rate of patients transferred the non-good-quality embryo in the group of overnight incubation culture was significantly higher than those in the group of conventional culture(36.36% vs. 25.89%pregnancy rate of patients transferred the good-quality blastocyst in the group of overnight incubation culture was significantly lower than those in the group of conventional culture(51.25% vs. 65.13%, P=0.040). Conclusion: Overnight incubation culture is beneficial to improve the treatment of non-good-quality frozen-thawed embryo, but it is not conducive to the treatment of good-quality frozenthawed blastocyst.
作者
吴睿
张丽蓉
胡志富
于成和
张若鹏
罗大极
Wu Rui;Zhang Lirong;Hu Zhifu;Yu Chenghe;Zhang Ruopeng;Luo Daji(College of Basic Medicine, Wuhan University, Wuhan 430071, China;The First Affiliated Hospital of Dali University,Dali, Yunnan 671000, China)
出处
《大理大学学报》
CAS
2019年第4期68-70,共3页
Journal of Dali University
关键词
胚胎
过夜培养
胚胎质量
冻融胚胎
embryo
overnight incubation culture
the quality of embryo
frozen-thawed embryo
