摘要
目的:探讨急性有机磷中毒病人中性粒细胞淋巴细胞比值(NLR)对其病情严重程度的预测价值。方法:选取2015年6月至2018年6月我院收治的资料完整的经口有机磷中毒病人80例。基于入院时胆碱酯酶活力将研究对象分为轻度组19例,中度组20例,重度组41例,另取同一时期健康体检者20例作为对照组。检测中性粒细胞和淋巴细胞计数并计算NLR,对病人一般资料进行均数比较,应用卡方检验对计数资料的差异进行比较,采用秩和检验和Spearman相关性检验对各组数据进行统计分析。结果:在轻度组中NLR波动在正常界限高值。随着有机磷中毒病人严重程度的增加,NLR逐渐下降。另外,NLR与血浆胆碱酯酶水平呈显著负相强相关性(P<0. 01)。因此可以作为评价有机磷农药中毒严重程度的评估指标。结论:NLR可以用作评估有机磷农药中毒病人血浆胆碱酯酶水平以外的参考指标。
Objective:To investigate the predictive value of neutrophils-lymphocytes ratio in the severity of acute organophosphorus poisoning.Methods:The data of 80 hospitalized patients with oral organophosphate poisoning from June 2015 to June 2018 were analyzed.Based on the cholinesterase activity on admission,the subjects were divided into three groups:mild(19 cases),moderate(20 cases)and severe(41 cases).Another 20 healthy people who underwent physical examination at the same time were taken as control group.Neutrophil and lymphocyte counts were measured and neutrophils-lymphocytes ratio(NLR)was calculated.Plasma cholinesterase,NLR,Chi-square test,rank sum test and Spearman correlation test were studied on the data of the first blood routine after admission.Results:In mild group,NLR fluctuation was at the high normal limit.As the severity of organophosphorus poisoning increased,NLR gradually decreased.In addition,NLR is negatively correlated with plasma cholinesterase level and can be used as an marker to assess the severity of organophosphorus pesticide poisoning.Conclusion:NLR on admission can be used as a reference marker other than plasma cholinesterase level in patients with organophosphorus pesticide poisoning.
作者
张敏
宫能凯
李倩
ZHANG Min;GONG Neng-kai;LI Qian(Department of Emergency Medicine,Yijishan Hospital of Wannan Medical College,Wuhu,Anhui 241001)
出处
《赣南医学院学报》
2019年第3期230-233,245,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
2018年度安徽芜湖市科技计划项目(编号:2018cg29)
