摘要
目的观察不同剂量螺内酯治疗难治性高血压的效果及对血压和脂代谢的影响。方法选择本院2016年5月至2018年5月收治的92例难治性高血压患者,以随机化原则分为对照组(n=46,40 mg/d螺内酯)和研究组(n=46,20 mg/d螺内酯)。比较两组的临床疗效、血压、血脂、生活质量及不良反应。结果研究组的治疗总有效率、治疗后3个月的各项生活质量评分均高于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者的SBP、DBP、LDL-C、TC、TG水平均降低,HDL-C水平均升高,且研究组优于对照组,差异具有统计学意义(P<0.05);研究组和对照组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论以小剂量螺内酯(20 mg/d)治疗难治性高血压,可有效降低血压,调节脂代谢,提升患者的生活质量,安全性高,值得临床推广应用。
Objective To observe the effect of different doses of spironolactone on refractory hypertension and its impact on blood pressure and lipid metabolism. Methods From May 2016 to May 2018, 92 patients with refractory hypertension admitted in our hospital were randomly divided into control group(46 cases, 40 mg/d spironolactone) and study group(46 cases,20 mg/d spironolactone). The clinical efficacy, blood pressure, blood lipid, quality of life and adverse reactions were compared between the two groups. Results The total effective rate of treatment and quality of life scores at 3 months after treatment in the study group were higher than those in the control group, and the differences were statistically significant(P <0.05). After treatment, the levels of SBP, DBP, LDL-C, TC and TG in both groups decreased, while the levels of HDL-C increased, those of the study group were better than the control group, and the differences were statistically significant(P<0.05). There was no significant difference in the total incidence of adverse reactions between the study group and the control group(P >0.05).Conclusion Low-dose spironolactone(20 mg/d) can effectively reduce blood pressure, regulate lipid metabolism and improve the quality of life of patients with refractory hypertension. It is safe and worthy of clinical application.
作者
郭亚妮
GUO Ya-ni(Shenhua Shendong General Hospital, Yulin 719315, China)
出处
《临床医学研究与实践》
2019年第12期20-22,共3页
Clinical Research and Practice
关键词
螺内酯
难治性高血压
血压
脂代谢
spironolactone
refractory hypertension
blood pressure
lipid metabolism
