摘要
锌指蛋白A20(也称TNFAIP3)是一种可在多种炎症条件,如LPS、IL-1、TNF-α等刺激下,被激活的具有去泛素化和泛素化双重功能的胞质蛋白。目前,A20被认为是NF-κB的负调控因子,具有免疫调节作用。最新研究表明,A20参与了过敏性哮喘的发生和发展。因此,该文对A20的起源、结构、生物学功能及其在过敏性哮喘中的作用进行综述,以期为过敏性哮喘的治疗和预防提供新的方法和思路。
A20 (also known as TNFAIP3) is a zinc finger protein with both ubiquitination and deubiquitination functions,which can be activated by a variety of inflammatory factors such as LPS,IL-1 and TNF-α.To date,A20 has been considered a negative regulator of NF-κB with immunomodulatory effects.And the latest researches have shown the involvement of A20 in the occurrence and development of various allergic diseases.This article reviews the origin,structure,and biological functions of A20 and its role in allergic asthma,through which new methods and ideas might be enlightened for the treatment and prevention of allergic asthma.
作者
袁为远
包凯帆
贾志荣
王晓钰
郑劼
洪敏
江国荣
YUAN Wei-yuan;BAO Kai-fan;JIA Zhi-rong;WANG Xiao-yu;ZHENG Jie;HONG Min;JIANG Guo-rong(College of Pharmacy,Nanjing University of Chinese Medicine,Jiangsu Key Lab for Pharmacology and Safety Evaluation ofChinese Materia Medica,Nanjing210023,China;Dept of Pharmacology,School of Medicine and Life Sciences,Nanjing University of Chinese Medicine,Nanjing210023,China;Suzhou Wu Men Yi Pai Research Institute,the AffiliatedSuzhou Hospital of TCM of Nanjing University of Chinese Medicine,Suzhou Jiangsu215003,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第5期607-611,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81473395
81373549)
江苏省自然科学基金资助项目(No BK20141466)
江苏省儿童呼吸疾病(中医药)重点实验室资助项目(No JKLPRD201405)
江苏高校优势学科建设工程资助项目
