摘要
原发性肝细胞癌是全球最常见的恶性肿瘤之一。肝细胞癌起病隐匿,早期临床症状多不明显,造成早期发现及诊断的难度较大,确诊时多属中晚期,且由于肝细胞癌的高侵袭转移和高复发率,导致肝细胞癌的死亡率极高。MicroRNAs(miRNAs)是长约22个核苷酸的高度保守的内源性非编码单链小RNA。肝脏内存在大量miRNAs,miRNAs不仅可以调节肝脏的生长发育,还与肝细胞癌的形成密切相关。在肝细胞癌形成的过程中,miRNAs可作为致癌基因或抑癌基因调节肿瘤细胞的分化、增殖、肿瘤形成、血管生成及侵袭和转移等。近十年来,随着对miRNAs在肝细胞癌形成过程中的分子机制研究的深入,越来越多研究表明,miRNAs可成为早期诊断肝细胞癌的灵敏的生物指标和有效的治疗靶点。
Hepatocellular carcinoma（ HCC） is one of the most common malignancies worldwide.Due to the difficulty of diagnosis in the early stage of HCC,most HCCs are diagnosed in intermediate-advanced stage.Moreover,the high invasion,metastasis and recurrence rate of HCC result in the high mortality of HCC.MicroRNAs（ miRNAs） are a class of highly conserved,endogenous,small,non-coding,single stranded RNA with the length of 22 nucleotides.There are plentiful of miRNAs in liver.MiRNAs not only can regulate the growth and development of liver,but also are closely related to the formation of HCC.In the process of HCC formation,miRNAs could function as oncogenes or tumor suppressor genes to regulate multiple biological processes related to HCC,including cell differentiation,proliferation,tumorigenesis,angiogenesis,invasion,and metastasis.With the intensive study of molecular mechanisms of miRNAs in the process of HCC formation,increasingly studies have revealed that miRNAs could become sensitive biomarkers and effective therapeutic targets for HCC.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2017年第4期445-449,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81573808)
广东省中医药局资助项目(No 20151038)
关键词
MIRNAS
肝细胞癌
致癌基因
抑癌基因
诊断
治疗
miRNAs
hepatocellular carcinoma
oncogenes
tumor suppressor genes
diagnosis
therapy
