摘要
目的分析2008-2017年河北省手足口病(hand-foot-mouth disease, HFMD)的流行病学及病原特征,为HFMD的防控提供科学依据。方法收集2008-2017年HFMD疫情资料和实验室检测结果,进行描述流行病学分析。结果 2008-2017年河北省累计报告HFMD病例690 368例,重症4 939例,死亡208例,年均发病率为95.53/10万。2009年,轻型病例报告病例数最多,而重症和死亡则是2010年。报告发病人数呈隔年增加但总体减少的趋势。2008年、2009年和2012年4～6月份间形成春夏季发病主高峰,2010年、2011年和2013-2017年5～7月份出现春夏主高峰,主峰值落在的月份呈向后延迟趋势。男女的性别比是1.59:1,死亡病例以散居儿童和幼托儿童为主。其它肠道病毒、肠道病毒71型(human enterovirus 71,EV-A71)和柯萨奇病毒A组16型(coxasckievirus A16,CV-A16)交替成为普通病例的主要病原,不同病例类型的病原构成不同且差异有统计学意义(χ~2=2 274.17,P<0.001)。结论报告死亡和重症病例数呈大幅减少趋势,应适时调整防控重点,提高对HFMD轻型病例的重视,进一步加强对其他肠道病原谱的监测。
Objective To analyze the epidemiological and pathogenic characteristics of hand-foot-mouth disease(HFMD)in Hebei Province from 2008 to 2017,so as to provide scientific evidence for prevention and control of HFMD.Methods The epidemic data and laboratory detection data of HFMD from 2008 to 2017 were collected and analyzed by descriptive epidemiology.Results From 2008 to 2017,a total of 690 368 cases of hand,foot and mouth disease,including 4 939 severe cases and 208 deaths were reported in Hebei Province,with an average annual incidence of 95.53/100 000.The largest number of reported light cases were 2009,while severe cases and deaths were in 2010.The number of reported cases increased every other year but decreased in general.In 2008,2009 and 2012,the main peak of the onset of spring and summer was formed from April to June.In 2010,2011 and 2013-2017,the main peak of the onset of spring and summer was from May to July.Main peak value in spring and summer showed a backward delayed trend.The sex ratio between men and women was 1.59:1.The majority of deaths case were scattered children and preschool case.Other enteroviruses,human enterovirus 71,(EV-A71)and coxasckievirus A16,(CV-A16)alternately became the main pathogens of common cases.The pathogenic composition of different cases was different and the difference was statistically significant(χ^2=2274.17,P<0.001).Conclusion The number of reported deaths and severe cases has decreased significantly.It is necessary to adjust the focus of prevention and control,pay more attention to the mild cases of FHMD,and further strengthen the monitoring of other enteroviruses pathogenic spectrum.
作者
朱宝增
赵文娜
刘莹莹
于秋丽
苏通
谢赟
李琦
ZHU Bao-zeng;ZHAO Wen-na;LIU Ying-ying;YU Qiu-li;SU Tong;XIE Yun;LI Qi(Public Health School,North China University of Science and Technology,Tangshan 063000,China;Hebei provincial Center for Disease Control and Prevention,Shijiazhuang 050021,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2019年第3期356-359,共4页
Chinese Journal of Disease Control & Prevention
基金
"十三五"国家科技重大专项课题(No.2018ZX10713002)
河北省科技计划项目(No.172777111D)~~
关键词
手足口病
流行病学特征
病原学
其它肠道病毒
Hand,foot and mouth disease
Epidemiologic characteristics
Pathogen
other enteroviruses
