摘要
目的探讨蒲参胶囊联合阿托伐他汀钙对老年动脉粥样硬化患者临床疗效。方法收集我院2015年12月至2016年12月收治的老年右侧颈动脉粥样硬化患者76例,按照随机数字表分为观察组和对照组(各38例)。其中对照组给予阿托伐他汀钙治疗,观察组在对照组基础上增加蒲参胶囊治疗,两组患者均连续治疗12个月。比较两组患者临床疗效及治疗期间不良反应发生情况。分析两组患者治疗前后血脂水平、颈动脉-中膜厚度(IMT)、颈动脉斑块面积、超敏C反应蛋白(hs-CRP)、VEGF、TGF-β1、VCAM-1以及P选择素水平变化情况。结果观察组为总有效率为94.74%,对照组为73.68%,差异具有统计学意义(P <0.05)。治疗前,两组患者血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)]水平、IMT、颈动脉斑块面积、血清hs-CRP、VEGF、TGF-β1、VCAM-1和P-选择素水平比较差异无统计学意义(P> 0.05);治疗后,两组患者TC、TG、LDL-C、IMT、颈动脉斑块面积、hs-CRP、VEGF、TGF-β1、VCAM-1和P-选择素水平均显著下降,HDL-C水平显著上升(P <0.05),且观察组相较于对照组,TC、TG、LDL-C、IMT、颈动脉斑块面积、hs-CRP、VEGF、TGF-β1、VCAM-1和P-选择素水平更低,HDL-C水平更高,差异具有统计学意义(P> 0.05)。治疗期间,两组患者均无不良反应现象发生。结论蒲参胶囊联合阿托伐他汀钙治疗老年动脉粥样硬化临床疗效较好,可改善患者血脂水平,调节内皮功能,下调炎性反应相关因子,稳定动脉粥样硬化斑块,安全性高。
Objective We aimed to investigate the effect of Pushen capsule combined with atorvastatin calcium on the clinical efficacy and VEGF,TGF-β1,VCAM-1 and P-selectin levels in elderly patients with athero-sclerosis. Methods Seventy-six elderly patients with right carotid atherosclerosis admitted to our hospital from De-cember 2015 to December 2016 were enrolled. The patients were divided into observation group(38 cases)and control group(38 cases)according to the random number table. The control group was treated with atorvastatin calcium,while the observation group was treated with Pushen capsule and atorvastatin calcium. Both of two groups were treated continuously for 12 months. The clinical efficacy and the occurrence of adverse reactions during the treatment were compared between the two groups. We analyzed the changes of blood lipid,carotidmedia thickness (IMT),carotid plaque area,hypersensitive C-reactive protein(hs-CRP),vascular endothelial growth factor (VEGF)transforming growth factor β1(TGF-β1),vascular cell adhesion factor(VCAM-1)and P-selectin levels before and after the treatment. Results The total effective rate was 94.74% in the observation group and 73.68% in the control group. The difference was statistically significant(P<0.05). Before treatment,there were no statistical differences between the two groups inthe blood lipids(total cholesterol(TC),triglyceride(TG),Low-density lipoprotein(LDL-C),high-density lipoprotein(HDL-C)levels,IMT,carotid plaque area,serum hs-CRP, VEGF,TGF-β1,VCAM-1 and P-selectin levels respectively(P > 0.05). After treatment,TC,TG,LDL-C, IMT,carotid plaque area,hs-CRP,VEGF,TGF-β1,VCAM-1 and P-selectin levels were significantly decreased than baseline levels in both groups,while HDL-C levels increased significantly(P<0.05). Compared with the control group,TC,TG,LDL-C,IMT,carotid plaque area,hs-CRP,VEGF,TGF-β1,VCAM-1 and P-selectin levels were lower in observation group,while the HDL-C levels were higher. The differences were statistically significant respectively(P<0.05). D
作者
汪海飞
赵亚西
郑江华
雍熙
陈镜全
尹洪顺
朱彦彬
陈开
WANG Haifei;ZHAO Yaxi;ZHENG Jianghua;YONG Xi;CHEN Jingquan;YIN Hongshun;ZHU Yanbin;CHEN Kai(Department of Vascular Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第5期809-813,共5页
The Journal of Practical Medicine
基金
川北医学院科研发展计划青年项目(编号:CBY13-A-QN02)
