摘要
目的:观察瑞舒伐他汀钙联合阿司匹林、尼莫地平治疗短暂性脑缺血发作(TIA)患者的效果。方法:回顾性分析2017年3月至2019年2月该院收治的92例TIA患者的临床资料,按照治疗方法不同将其分为对照组和观察组各46例。两组均进行基础治疗,在此基础上,对照组予以阿司匹林联合尼莫地平治疗,观察组在对照组基础上增加瑞舒伐他汀钙治疗,两组均持续治疗1个月。比较两组临床疗效,治疗前后血脂指标[低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)]水平、血液流变学指标[全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)]水平,以及不良反应发生率。结果:观察组治疗总有效率为93.48%(43/46),高于对照组的76.09%(35/46),差异有统计学意义(P<0.05);治疗后,观察组LDL-C、TG、TC、HBV、LBV、PV水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:瑞舒伐他汀钙联合阿司匹林、尼莫地平治疗TIA患者可提高治疗总有效率,降低血脂指标和血液流变学指标水平,效果优于阿司匹林联合尼莫地平治疗。
Objective:To observe effects of Rosuvastatin calcium combined with Aspirin and Nimodipine in treatment of patients with transient ischemic attack(TIA).Methods:The clinical data of 92 patients with TIA admitted to the hospital from March 2017 to February 2019 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,46 cases in each group.Both groups received basic treatment.On this basis,the control group was treated with Aspirin combined with Nimodipine,while the observation group was treated with Rosuvastatin calcium on the basis of those of the control group.Both groups were treated for 1 month.The clinical efficacy,the blood lipid indexes[low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)]levels,the hemorheology indexes[whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),plasma viscosity(PV)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 93.48%(43/46),which was higher than 76.09%(35/46)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LDL-C,TG,TC,HBV,LBV and PV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Rosuvastatin calcium combined with Aspirin and Nimodipine in the treatment of the TIA patients can improve the total effective rate of treatment,reduce the levels of blood lipid indexes and hemorheology indexes.Moreover,it is superior to Aspirin combined with Nimodipine treatment.
作者
郭宗坤
GUO Zongkun(First Ward of Encephalopathy of Zhoukou Hospital of Traditional Chinese Medicine,Zhoukou 466000 Henan,China)
出处
《中国民康医学》
2023年第20期30-33,共4页
Medical Journal of Chinese People’s Health
