摘要
细菌耐药问题已对全球公共卫生构成了重大的威胁,研发新的抗菌药物成了紧迫的任务。氨酰-tRNA合成酶作为催化特定氨基酸与tRNA结合的关键酶,在蛋白质合成中发挥了重要作用,由于真核细胞与原核细胞在酶的精细结构上存在差异,为设计针对细菌氨酰-tRNA合成酶的抑制剂提供结构基础。本文对细菌氨酰-tRNA合成酶的结构、作用机制及分类进行概述,并从酶抑制剂的来源出发,对针对此靶点的抗感染药物研究现状进行系统综述。
Bacterial resistance has become a major threat to global public health,so the discovery of new antimicrobial agents has become an urgent task.As a key enzyme that catalyzes the binding of specific amino acids to tRNA,aminoacyl tRNA synthase plays an important role in protein synthesis.Due to the differences in the enzyme fine structure between eukaryotic and prokaryotic cells,it provides a structural basis for the design of inhibitors against bacterial aminoacyl tRNA synthase.In this paper,the structure,mechanism and classification of bacterial aminoacyl tRNA synthase were summarized,and the research status of anti-infective drugs aiming at this target was systematically discussed from the source of enzyme inhibitors.
作者
张硕
李卓荣
ZHANG Shuo;LI Zhuorong(Institute of Medicinal Biotechnology,Chinese Academy of Medical Science & Peking Union Medical College,Beijing 100050,China)
出处
《药学研究》
CAS
2019年第3期125-134,139,共11页
Journal of Pharmaceutical Research
基金
国家自然科学基金(No.81773585)
中国医学科学院医学与健康科技创新工程(No.2017-I2M-1-012)
