摘要
目的：总结第五代头孢菌素类药物的药理学特点及临床应用。方法选取已经上市的两种第五代头孢菌素类药物（头孢洛林、头孢吡普）作为研究对象，对其药理学特点、药效学、耐药性与不良反应以及临床应用等方面进行综述。结果与其他头孢菌素类药物比较，第五代头孢菌素类药物的抗菌谱更广且无严重不良反应，特别是对酶的稳定性较好，耐药率低，对 MRSA 活性较高，目前作为皮肤感染、软组织感染等疾病的批准临床用药。结论第五代头孢菌素类药物具有抗菌谱广、抗菌效力强、对酶的稳定性良好及安全性高等优势，应用前景较好。
Objective To summary the pharmacological characteristics of the fifth generation cephalosporins and clinical application. Methods Two kinds of the fifth generation cephalosporins（cefotaximeLorraine,ceftobiprole）were already marketed were selected as the research objects. Pharmacology and clinical application of them including the phar-macodynamics,drug resistance and adverse reaction were analyzed. Results Compared with other cephalosporins,broader antibacterial spectrum and no serious adverse reactions of the fifth generation cephalosporins,especially on enzyme stability was good,low rate of resistance,the higher MRSA activity. At present,it is used for the infection of the skin and soft tis-sue infection as the clinical approved medication. Conclusions The fifth generation of cephalosporins has broad antibacte-rial spectrum,strong antibacterial effect on enzyme stability,good and high security and good application prospect.
出处
《中国实用医刊》
2016年第10期125-126,共2页
Chinese Journal of Practical Medicine
关键词
第五代头孢菌素类药物
药理学
临床应用
Fifth generation cephalosporins
Pharmacology
Clinical application
