摘要
胰岛素抵抗是多种代谢性疾病的共同病理基础。笔者基于近10年国内外胰岛素抵抗发病机制及针刺治疗胰岛素抵抗机制的相关研究,从以下几方面进行了分析总结:(1)针刺对中枢神经元的影响;(2)针刺对外周靶器官的影响;(3)针刺对机体炎性反应及氧化应激的影响;(4)针刺对胰岛β细胞的影响。笔者认为今后的研究应重视腧穴特异性、配伍方法及刺激参数对针刺治疗胰岛素抵抗的影响,这对揭示针刺的临床应用规律,优化临床治疗方案具有重要的意义。
Insulin resistance(IR)is a common pathophysiological basis of many chronic diseases,such as obesity,type2 diabetes mellitus(T2 DM),nonalcoholic fatty liver disease,cerebral vascular disease,cardiovascular and neurodegenerative diseases,etc.Acupuncture therapy has been demonstrated to have a positive role in reducing IR level in clinical practice.In the present paper,we summarized development of researches on the mechanism of acupuncture therapy underlying improvement of IR in recent 10 years from 1)regulating expression of hypothalamic phosphatidylinositol-3-kinase(PI3 K)-p85 and PI3 K-P110 proteins in obesity rats;2)regulating the levels of some related proteins of insulin target tissues(liver and skeletal muscle),such as insulin receptor substrate-1(IRS)-1 and-2,glucose transporter mRNAs and proteins,sterol regulatory element-binding protein 1(SREBP-1)and fatty acid synthetase proteins;3)suppressing inflammatory reaction of liver tissue and down-regulating serum adiponectin in T2 DM rats;4)raising the activity of superoxide dismutase(SOD)and reducing the levels of reactive oxygen species,and malondialdehyde(MDA)contents of quadriceps femoris in spontaneous IR rats;and 5)attenuating structural injury of pancreas islet and apoptosis of pancreaticβcells in diabetes rats.Multi-levels and various systems of the neuro-endocrine-immune networks are involved in the actions of acupuncture in the improvement of IR.In the future,more attention should be paid to the study on the acupoint specificity,suitable acupoint combinations and stimulus parameters in clinical treatment of IR related various metabolic diseases,further optimizing clinical treatment protocols.
作者
李知行
张海华
蓝丹纯
陈小砖
孙健
LI Zhi-xing;ZHANG Hai-hua;LAN Dan-chun;CHEN Xiao-zhuan;SUN Jian(Department of Soft Tissue Traumatology,Shenzhen 518033,Guangdong Province,China;Massage Department, Shenzhen City Hospital of Traditional Chinese Medicine,Shenzhen 518033, Guangdong Province,China;Department of Acupuncture-moxibustion,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong Province;Traditional Therapy Department of Fangchun Branch Hospial, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120)
出处
《针刺研究》
CAS
CSCD
北大核心
2019年第3期231-234,共4页
Acupuncture Research
基金
国家自然科学基金资助项目(No.81774394
81303042)
国家自然科学基金青年项目(No.81804167)
深圳市卫生系统科研项目资助(No.SZBC2017025)
关键词
针刺
胰岛素抵抗
代谢性疾病
下丘脑
胰岛素抵抗靶向外周组织
综述
Acupuncture
Insulin resistance
Metabolic diseases
Hypothalamus
Insulin targeting peripheral tissues
Review
