摘要
正常甲状腺滤泡上皮细胞和分化型甲状腺癌(DTC)细胞膜上表达钠/碘转运体(NIS),在促甲状腺激素(TSH)刺激下可充分摄取碘。尽可能减少体内稳定碘储存、保证充足的131I进入残余甲状腺组织和DTC病灶内是放射性碘(RAI)治疗的先决条件。明确低碘准备的相关事宜,有助于DTC患者的RAI治疗。该文综述低碘准备的程度、持续时间及对RAI治疗效果的影响等。
Normal thyroid follicular epithelial cells and differentiated thyroid carcinoma (DTC) cells have the unique ability to take up iodine under the stimulation of thyroid stimulating hormone (TSH) via a membrane-based sodium/iodide symporter (NIS). Depleting plasma iodine concentration and ensuring sufficient amount of ^131I uptake into remnant or cancer cells serve as the basis for radioactive iodine (RAI) therapy. Knowledge of the importance of low iodine preparation contributes to RAI therapy for DTC patients. This review summarizes the optimal extent, duration and impact of low iodine preparation on outcomes of RAI therapy.
作者
林润龙
于璟
Lin Runlong;Yu Jing(Department of Nuclear Medicine, the Second Hospital of Dalian Medical University, Dalian 116000, China)
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2019年第3期182-186,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
