摘要
目的探讨应用布洛芬预防早产儿颅内出血的临床效果及对氨基末端脑钠肽前体(NT-proBNP)、血浆内皮素(ET-1)水平影响。方法选取2016年1月至2017年12月浙江省台州医院经纳入及排除标准筛选后早产儿112例为研究对象。采用随机数字表法分为观察组和对照组,每组56例。对照组进行常规治疗,观察组在此基础上给予布洛芬进行预防治疗,比较两组患儿颅内出血发生率、临床指标及血清NT-proBNP、ET-1水平。结果观察组患儿发生颅内出血10例(17.86%),对照组患儿发生颅内出血17例(30.36%),两组颅内出血发生率差异有统计学意义(χ^2=12.472,P<0.05)。与对照组比较,观察组患儿血清NT-proBNP、ET-1水平明显下降,差异有统计学意义(P<0.05)。两组患儿肝功能、肾功能、凝血异常及少尿比较,差异无统计学意义(P>0.05)。两组患儿的需氧时间和恢复出生体质量时间,差异有统计学意义(P<0.05);两组患儿喂养不耐受及胃出血发生率差异无统计学意义(P>0.05)。结论应用布洛芬混悬液能够有效预防早产儿颅内出血,且安全性较高,无明显毒副作用,值得临床使用。
Objective To investigate the clinical effect of ibuprofen on preventing intracranial hemorrhage in premature infants and its influence on the levels of NT-proBNP and ET-1.MethodsFrom January 2016 to December 2017,112 premature infants in Taizhou Hospital were selected as study objects after screening by inclusion and exclusion criteria.The infants were randomly divided into observation group and control group according to the digital table,with 56 cases in each group.The control group was treated with routine therapy,and the observation group was given ibuprofen prophylaxis.The incidence of intracranial hemorrhage,clinical index and serum NT-proBNP,ET-1 levels were compared between the two groups.ResultsThere was significant difference in the incidence rate of intracranial hemorrhage between the observation group(17.86%)and the control group(30.36%)(χ^2=12.472,P<0.05).The serum levels of NT-proBNP and ET-1 in the observation group were significantly lower than those in the control group(all P<0.05).There were no statistically significant differences in liver function,renal function,coagulation abnormality and oliguria between the two groups(all P>0.05).There were no statistically significant differences in feeding intolerance and gastric hemorrhage between the two groups(all P>0.05).ConclusionThe application of ibuprofen suspension can effectively prevent intracranial hemorrhage in premature infants,which is worthy of clinical use.
作者
金海华
卢洪萍
Jin Haihua;Lu Hongping(Department of Neonatology,Taizhou Hospital,Taizhou,Zhejiang,317000,China)
出处
《中国基层医药》
CAS
2019年第3期307-309,共3页
Chinese Journal of Primary Medicine and Pharmacy
