摘要
目的探讨曲美他嗪联合辅酶Q10治疗高龄慢性心力衰竭的效果。方法选取2017年6月～2018年6月我院心内科收治的96例高龄慢性心力衰竭患者作为研究对象,按照随机数字表法分为观察组与对照组,每组各48例。对照组在慢性心力衰竭常规治疗基础上加用曲美他嗪,观察组在对照组基础上加用辅酶Q10,观察两组患者治疗前后血清N末端脑钠肽前体(NT-proBNP)、人心型脂肪酸结合蛋白(H-FABP)、Nexilin及心功能的变化。结果两组患者治疗后的血清NT-proBNP、H-FABP、Nexilin水平均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的血清NT-proBNP、H-FABP、Nexilin水平明显低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的每搏输出量(SV)、左心室射血分数(LVEF)水平高于对照组,左心室收缩末容积指数(LVESVI)、左室舒张末容积指数(LVEDVI)水平低于对照组,差异有统计学意义(P<0.05)。结论曲美他嗪联合辅酶Q10能够显著降低高龄慢性心力衰竭患者的血清NT-proBNP、H-FABP、Nexilin水平,同时可提高心功能,值得临床推广。
Objective To investigate the efficacy of Trimetazidine combined with coenzyme Q10 in the treatment of chronic heart failure. Methods A total of 96 elderly patients with chronic heart failure admitted to cardiology department from June 2017 to June 2018 were selected as the subjects, and divided into the treatment group and the control group by random number table method, with 48 cases in each group. The control group was given the routine treatment for chronic heart failure in addition to Trimetazidine. Coenzyme Q10 was added to the treatment group on the basis of the control group. The serum N-terminal pro brain natriuretic peptide (NT-proBNP), heart fatty acid binding protein (H-FABP), Nexilin and cardiac function were compared between the two groups before and after treatment. Results After treatment, the serum levels of NT-proBNP, H-FABP and Nexilin in the two groups were lower than those before treatment, and the differences were statistically significant (P<0.05). The serum levels of NT-proBNP, H-FABP and Nexilin in the treatment group were lower than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the level of stroke volume (SV) and left ventricular ejection fraction (LVEF) in the observation group were higher than those in the control group, and Left ventricular end-systolic volume index (LVESVI) and Left ventricular end-diastolic volume index (LVEDVI) were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Trimetazidine combined with coenzyme Q10 can significantly reduce the levels of NT-proBNP, H-FABP and Nexilin in elderly patients with chronic heart failure, and improve cardiac function, which is worthy of clinical promotion.
作者
黄燕妮
HUANG Yan-ni(The Fourth Department of Internal Medicine, Puning People′s Hospital, Guangdong Province, Puning 515300, China)
出处
《中国当代医药》
2019年第7期61-64,共4页
China Modern Medicine
